Mitochondrial network complexity and pathological decrease in complex I activity are tightly correlated in isolated human complex I deficiency

Complex I (NADH:ubiquinone oxidoreductase) is the largest multisubunit assembly of the oxidative phosphorylation system, and its malfunction is associated with a wide variety of clinical syndromes ranging from highly progressive, often early lethal, encephalopathies to neurodegenerative disorders in... View More