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Developmental Decrease in NMDA Receptor Desensitization Associated with Shift to Synapse and Interaction with Postsynaptic Density-95

Published in The Journal of Neuroscience • Dec 3, 2003
NobleIDNI7P63W48R74S13
Authors:
Bo Li
,
Yo Otsu
,
Timothy H. Murphy

Abstract

NMDA receptors (NMDARs) play a crucial role in neuronal development, synaptic plasticity, and excitotoxicity; therefore, regulation of NMDAR function is important in both physiological and pathological conditions. Previous studies indicate that the NMDAR-mediated synaptic current decay rate increase...

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