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TNF-α induces a decrease in eNOS promoter activity

Published in American Journal of Physiology-Lung Cellular and Molecular Physiology • Feb 1, 2004
Authors:
Paul Neumann
,
Nancy Gertzberg
,
Arnold Johnson

Abstract

We determined whether TNF-α induces a decrease in activity of the promoter for the endothelial nitric oxide synthase (eNOS) gene in pulmonary microvessel endothelial monolayers (PMEM). eNOS promoter activity was assessed in PMEM transfected with plasmids coding the wild-type (F1: -1600 nt from trans...

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