Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are  suppressed by HIV nucleocapsid protein

E. Cameron, Craig; Ghosh, Madhumita; F. J. Le Grice, Stuart; J. Benkovic, Stephen

doi:10.1073/pnas.94.13.6700

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Mutations in HIV reverse transcriptase which alter RNase H activity and decrease strand transfer efficiency are suppressed by HIV nucleocapsid protein

Published in Proceedings of the National Academy of Sciences • Jun 24, 1997

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Authors:

Craig E. Cameron

,

Madhumita Ghosh

,

Stuart F. J. Le Grice

Abstract

Structural studies of authentic HIV reverse transcriptase (RT) suggest a role for the p51 carboxyl terminus in forming an active RNase H conformation [Rodgers, D. W., Gamblin, S. J., Harris, B. A., Ray, S., Culp, J. S., Hellmig, B., Woolf, D. J., Debouck, C. & Harrison, S. C. (1995) Proc. Natl. Acad...

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