PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study

D. Singhi, Aatur; I. Wald, Abigail; Smith, Katelyn; Wolkenstein, Lynn; D. Bubar, Robert; Diaz-Aragon, Ricardo; Grupillo, Maria; Guckin, Danielle; Lai, Yi-Tak; E. Brand, Randall; McGrath, Kevin; G. Park, Walter; R. Pfau, Patrick; M. Polanco, Patricio; Kubiliun, Nisa; DeWitt, John; J. Easler, Jeffrey; Dam, Aamir; R. Mok, Shaffer; B. Wallace, Michael; A. Boone, Brian; Marsh, Wallis; Thakkar, Shyam; J. Fairley, Kimberly; Afghani, Elham; Bhat, Yasser; Ramrakhiani, Sanjay; Nasr, John; R. Thiruvengadam, Nikhil; Khalid, Asif; Fasanella, Kenneth; Chennat, Jennifer; Das, Rohit; Singh, Harkirat; Slivka, Adam; Gabbert, Charles; Sawas, Tarek; Tielleman, Thomas; Dutch Vanderveldt, Hendrikus; Tavakkoli, Anna; M. Smith, Lynette; H. Singhi, Anju; A. Singhi, Sara; Romutis, Stephanie; Mahmood, Sultan; E. Hosmer, Amy; McNabb-Baltar, Julia; Marie Lennon, Anne; H. Hruban, Ralph; Shaker, Nuha; Paniccia, Alessandro; Zureikat, Amer; K. Lee, Kenneth; Ongchin, Melanie; Zeh, Herbert; Minter, Rebecca; Max Schmidt, C.; He, Jin; N. Nikiforova, Marina

doi:10.1245/s10434-025-18848-8

Public

PancreaSeq Genomic Classifier (PancreaSeq GC) Improves Pancreatic Cyst Classification and Detection of Advanced Neoplasia: A Multi-institutional Validation Study

Published in Annals of Surgical Oncology • Dec 12, 2025

NobleIDNI6P15W94R66S92

Authors:

Aatur D. Singhi

,

Abigail I. Wald

,

Katelyn Smith

Abstract

Abstract Background The preoperative classification of pancreatic cysts and detection of advanced neoplasia (high-grade dysplasia/pancreatic ductal adenocarcinoma [PDAC]) represents a significant diagnostic challenge. A prospective, multi-institutional study found that DNA-based testing (PancreaSeq)...

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