Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity

Benbrook, D M; Madler, M M; Spruce, L W; Birckbichler, P J; Nelson, E C; Subramanian, S; Weerasekare, G M; Gale, J B; Patterson, M K; Wang, B; Wang, W; Lu, S; Rowland, T C; DiSivestro, P; Lindamood, C; Hill, D L; Berlin, K D

doi:10.1021/jm970196m

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Biologically active heteroarotinoids exhibiting anticancer activity and decreased toxicity.

Published in Journal of medicinal chemistry • Oct 24, 1997

Authors:

D M Benbrook

,

M M Madler

,

L W Spruce

Abstract

A series of retinoids, containing heteroatoms in a cyclic ring and called heteroarotinoids, were synthesized, and their biological activity was evaluated using tissue culture lines that have measurable responses to trans-retinoic acid (t-RA). Transglutaminase (TGase) was assessed in the human erythr...

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