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Multiple Sclerosis

Published in An Introduction to Evolutionary Medicine • Dec 18, 2026
Authors:
Alan D Penman
,
Joe Alcock

Abstract

Three main hypotheses—not mutually exclusive—have been proposed to explain the increasing frequency of multiple sclerosis (MS) in the past 50–60 years, and especially in the past 20 years: (a) an antagonistic pleiotropic effect of immune system genes; (b) the hygiene/“old friends” hypothesis; and (c...

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