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Intermittent low-efficiency hemodiafiltration causes a marked decrease in ampicillin and sulbactam plasma concentration in dogs with oliguric acute kidney injury

Published • Jan 1, 2026
Authors:
Amédée André
,
Bernadette Espana
,
Alexandra Nectoux

Abstract

Dogs with oliguric acute kidney injury (AKI) of infectious etiology are frequently managed with renal replacement therapy (RRT) and β-lactam antibiotics. Ampicillin and sulbactam are small, hydrophilic, renally eliminated molecules susceptible to extracorporeal clearance during RRT, yet the magnitud...

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