Electronics and Telecommunications Research Institute

Abstract Somatic mutations in cancer genomes are caused by multiple mutational processes, each of which generates a characteristic mutational signature 1 . Here, as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 2 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), we characterized mutational signatures using 84,729,690 somatic mutations from 4,645 whole-genome and 19,184 exome sequences that encompass most types of cancer. We identified 49 single-base-substitution, 11 doublet-base-substitution, 4 clustered-base-substitution and 17 small insertion-and-deletion signatures. The substantial size of our dataset, compared with previous analyses 3–15 , enabled the discovery of new signatures, the separation of overlapping signatures and the decomposition of signatures into components that may represent associated—but distinct—DNA damage, repair and/or replication mechanisms. By estimating the contribution of each signature to the mutational catalogues of individual cancer genomes, we revealed associations of signatures to exogenous or endogenous exposures, as well as to defective DNA-maintenance processes. However, many signatures are of unknown cause. This analysis provides a systematic perspective on the repertoire of mutational processes that contribute to the development of human cancer.

Abstract Cancer is driven by genetic change, and the advent of massively parallel sequencing has enabled systematic documentation of this variation at the whole-genome scale 1–3 . Here we report the integrative analysis of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). We describe the generation of the PCAWG resource, facilitated by international data sharing using compute clouds. On average, cancer genomes contained 4–5 driver mutations when combining coding and non-coding genomic elements; however, in around 5% of cases no drivers were identified, suggesting that cancer driver discovery is not yet complete. Chromothripsis, in which many clustered structural variants arise in a single catastrophic event, is frequently an early event in tumour evolution; in acral melanoma, for example, these events precede most somatic point mutations and affect several cancer-associated genes simultaneously. Cancers with abnormal telomere maintenance often originate from tissues with low replicative activity and show several mechanisms of preventing telomere attrition to critical levels. Common and rare germline variants affect patterns of somatic mutation, including point mutations, structural variants and somatic retrotransposition. A collection of papers from the PCAWG Consortium describes non-coding mutations that drive cancer beyond those in the TERT promoter 4 ; identifies new signatures of mutational processes that cause base substitutions, small insertions and deletions and structural variation 5,6 ; analyses timings and patterns of tumour evolution 7 ; describes the diverse transcriptional consequences of somatic mutation on splicing, expression levels, fusion genes and promoter activity 8,9 ; and evaluates a range of more-specialized features of cancer genomes 8,10–18 .

There is a growing demand for flexible and soft electronic devices. In particular, stretchable, skin‐mountable, and wearable strain sensors are needed for several potential applications including personalized health‐monitoring, human motion detection, human‐machine interfaces, soft robotics, and so forth. This Feature Article presents recent advancements in the development of flexible and stretchable strain sensors. The article shows that highly stretchable strain sensors are successfully being developed by new mechanisms such as disconnection between overlapped nanomaterials, crack propagation in thin films, and tunneling effect, different from traditional strain sensing mechanisms. Strain sensing performances of recently reported strain sensors are comprehensively studied and discussed, showing that appropriate choice of composite structures as well as suitable interaction between functional nanomaterials and polymers are essential for the high performance strain sensing. Next, simulation results of piezoresistivity of stretchable strain sensors by computational models are reported. Finally, potential applications of flexible strain sensors are described. This survey reveals that flexible, skin‐mountable, and wearable strain sensors have potential in diverse applications while several grand challenges have to be still overcome.

We consider the problem of routing in intermittently connected networks. In such networks there is no guarantee that a fully connected path between source and destination exist at any time, rendering traditional routing protocols unable to deliver messages between hosts. We propose a probabilistic routing protocol for such networks.

Human activity recognition is an important area of computer vision research. Its applications include surveillance systems, patient monitoring systems, and a variety of systems that involve interactions between persons and electronic devices such as human-computer interfaces. Most of these applications require an automated recognition of high-level activities, composed of multiple simple (or atomic) actions of persons. This article provides a detailed overview of various state-of-the-art research papers on human activity recognition. We discuss both the methodologies developed for simple human actions and those for high-level activities. An approach-based taxonomy is chosen that compares the advantages and limitations of each approach. Recognition methodologies for an analysis of the simple actions of a single person are first presented in the article. Space-time volume approaches and sequential approaches that represent and recognize activities directly from input images are discussed. Next, hierarchical recognition methodologies for high-level activities are presented and compared. Statistical approaches, syntactic approaches, and description-based approaches for hierarchical recognition are discussed in the article. In addition, we further discuss the papers on the recognition of human-object interactions and group activities. Public datasets designed for the evaluation of the recognition methodologies are illustrated in our article as well, comparing the methodologies' performances. This review will provide the impetus for future research in more productive areas.

A new class of organic nanoparticles (CN-MBE nanoparticles) with a mean diameter of ca. 30-40 nm, which exhibit a strongly enhanced fluorescence emission, were prepared by a simple reprecipitation method. CN-MBE (1-cyano-trans-1,2-bis-(4'-methylbiphenyl)ethylene) is very weakly fluorescent in solution, but the intensity is increased by almost 700 times in the nanoparticles. Enhanced emission in CN-MBE nanoparticles is attributed to the synergetic effect of intramolecular planarization and J-type aggregate formation (restricted excimer formation) in nanopaticles. On/off fluorescence switching for organic vapor was demonstrated with CN-MBE nanoparticles.

We introduce a novel technique for knowledge transfer, where knowledge from a pretrained deep neural network (DNN) is distilled and transferred to another DNN. As the DNN performs a mapping from the input space to the output space through many layers sequentially, we define the distilled knowledge to be transferred in terms of flow between layers, which is calculated by computing the inner product between features from two layers. When we compare the student DNN and the original network with the same size as the student DNN but trained without a teacher network, the proposed method of transferring the distilled knowledge as the flow between two layers exhibits three important phenomena: (1) the student DNN that learns the distilled knowledge is optimized much faster than the original model, (2) the student DNN outperforms the original DNN, and (3) the student DNN can learn the distilled knowledge from a teacher DNN that is trained at a different task, and the student DNN outperforms the original DNN that is trained from scratch.

Electrons in correlated insulators are prevented from conducting by Coulomb repulsion between them. When an insulator-to-metal transition is induced in a correlated insulator by doping or heating, the resulting conducting state can be radically different from that characterized by free electrons in conventional metals. We report on the electronic properties of a prototypical correlated insulator vanadium dioxide in which the metallic state can be induced by increasing temperature. Scanning near-field infrared microscopy allows us to directly image nanoscale metallic puddles that appear at the onset of the insulator-to-metal transition. In combination with far-field infrared spectroscopy, the data reveal the Mott transition with divergent quasi-particle mass in the metallic puddles. The experimental approach used sets the stage for investigations of charge dynamics on the nanoscale in other inhomogeneous correlated electron systems.

We propose joint spatial division and multiplexing (JSDM), an approach to multiuser MIMO downlink that exploits the structure of the correlation of the channel vectors in order to allow for a large number of antennas at the base station while requiring reduced-dimensional channel state information at the transmitter (CSIT). JSDM achieves significant savings both in the downlink training and in the CSIT uplink feedback, thus making the use of large antenna arrays at the base station potentially suitable also for frequency division duplexing (FDD) systems, for which uplink/downlink channel reciprocity cannot be exploited. In the proposed scheme, the multiuser MIMO downlink precoder is obtained by concatenating a prebeamforming matrix, which depends only on the channel second-order statistics, with a classical multiuser precoder, based on the instantaneous knowledge of the resulting reduced dimensional “effective” channel matrix. We prove a simple condition under which JSDM incurs no loss of optimality with respect to the full CSIT case. For linear uniformly spaced arrays, we show that such condition is approached in the large number of antennas limit. For this case, we use Szego's asymptotic theory of Toeplitz matrices to show that a DFT-based prebeamforming matrix is near-optimal, requiring only coarse information about the users angles of arrival and angular spread. Finally, we extend these ideas to the case of a 2-D base station antenna array, with 3-D beamforming, including multiple beams in the elevation angle direction. We provide guidelines for the prebeamforming optimization and calculate the system spectral efficiency under proportional fairness and max-min fairness criteria, showing extremely attractive performance. Our numerical results are obtained via asymptotic random matrix theory, avoiding lengthy Monte Carlo simulations and providing accurate results for realistic (finite) number of antennas and users.

Abstract Cancer develops through a process of somatic evolution 1,2 . Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes 3 . Here, by whole-genome sequencing analysis of 2,658 cancers as part of the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA) 4 , we reconstruct the life history and evolution of mutational processes and driver mutation sequences of 38 types of cancer. Early oncogenesis is characterized by mutations in a constrained set of driver genes, and specific copy number gains, such as trisomy 7 in glioblastoma and isochromosome 17q in medulloblastoma. The mutational spectrum changes significantly throughout tumour evolution in 40% of samples. A nearly fourfold diversification of driver genes and increased genomic instability are features of later stages. Copy number alterations often occur in mitotic crises, and lead to simultaneous gains of chromosomal segments. Timing analyses suggest that driver mutations often precede diagnosis by many years, if not decades. Together, these results determine the evolutionary trajectories of cancer, and highlight opportunities for early cancer detection.

Atomically thin forms of layered materials, such as conducting graphene, insulating hexagonal boron nitride (hBN), and semiconducting molybdenum disulfide (MoS2), have generated great interests recently due to the possibility of combining diverse atomic layers by mechanical "stacking" to create novel materials and devices. In this work, we demonstrate field-effect transistors (FETs) with MoS2 channels, hBN dielectric, and graphene gate electrodes. These devices show field-effect mobilities of up to 45 cm(2)/Vs and operating gate voltage below 10 V, with greatly reduced hysteresis. Taking advantage of the mechanical strength and flexibility of these materials, we demonstrate integration onto a polymer substrate to create flexible and transparent FETs that show unchanged performance up to 1.5% strain. These heterostructure devices consisting of ultrathin two-dimensional (2D) materials open up a new route toward high-performance flexible and transparent electronics.

Visible light communication refers to shortrange optical wireless communication using visible light spectrum from 380 to 780 nm. Enabled by recent advances in LED technology, IEEE 802.15.7 supports high-data-rate visible light communication up to 96 Mb/s by fast modulation of optical light sources which may be dimmed during their operation. IEEE 802.15.7 provides dimming adaptable mechanisms for flicker-free high-data-rate visible light communication.

Abstract A key mutational process in cancer is structural variation, in which rearrangements delete, amplify or reorder genomic segments that range in size from kilobases to whole chromosomes 1–7 . Here we develop methods to group, classify and describe somatic structural variants, using data from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA), which aggregated whole-genome sequencing data from 2,658 cancers across 38 tumour types 8 . Sixteen signatures of structural variation emerged. Deletions have a multimodal size distribution, assort unevenly across tumour types and patients, are enriched in late-replicating regions and correlate with inversions. Tandem duplications also have a multimodal size distribution, but are enriched in early-replicating regions—as are unbalanced translocations. Replication-based mechanisms of rearrangement generate varied chromosomal structures with low-level copy-number gains and frequent inverted rearrangements. One prominent structure consists of 2–7 templates copied from distinct regions of the genome strung together within one locus. Such cycles of templated insertions correlate with tandem duplications, and—in liver cancer—frequently activate the telomerase gene TERT . A wide variety of rearrangement processes are active in cancer, which generate complex configurations of the genome upon which selection can act.

We report ultraslow group velocities of light in an optically dense crystal of Pr doped Y2SiO5. Light speeds as slow as 45 m/s were observed, corresponding to a group delay of 66 micros. Deceleration and "stopping" or trapping of the light pulse was also observed. These reductions of the group velocity are accomplished by using a sharp spectral feature in absorption and dispersion that is produced by resonance Raman excitation of a ground-state spin coherence.

This paper presents a reversible or lossless watermarking algorithm for images without using a location map in most cases. This algorithm employs prediction errors to embed data into an image. A sorting technique is used to record the prediction errors based on magnitude of its local variance. Using sorted prediction errors and, if needed, though rarely, a reduced size location map allows us to embed more data into the image with less distortion. The performance of the proposed reversible watermarking scheme is evaluated using different images and compared with four methods: those of Kamstra and Heijmans, Thodi and Rodriguez, and Lee et al. The results clearly indicate that the proposed scheme can embed more data with less distortion.

Since the start of Bitcoin in 2008[1], blockchain technology emerged as the next revolutionary technology. Though blockchain started off as a core technology of Bitcoin, its use cases are expanding to many other areas including finances, Internet of Things (IoT), security and such[2]. Currently, many private and public sectors are diving into the technology[3]. Aside from that, as software and hardware improve, we would see the beginning of IoT. And those IoT devices need to communicate and synchronize with each other. But in situations where more than thousands or tens of thousands of IoT devices connected, we expect that using current model of server-client may have some limitations and issues while in synchronization. So, we propose using blockchain to build IoT system. Using blockchain, we can control and configure IoT devices. We manage keys using RSA public key cryptosystems where public keys are stored in Ethereum and private keys are saved on individual devices. Specifically, we choose Ethereum as our blockchain platform because using its smart contract, we can write our own Turing-complete code to run on top of Ethereum. Thus, we can easily manage configuration of IoT devices and build key management system. Even though we can simply use account as a key management system, which most of blockchain platform supports, we decide to use Ethereum because we can manage the system in a more fine-grained way. For the proof of a concept, we use a few IoT devices instead of a full system of IoT system, which consists of thousands of IoT devices. But in our later study, we would like to build a fully scaled IoT system using blockchain.

Tunable Metamaterials The electromagnetic response of metamaterials gives rise to exciting phenomena such as cloaking, negative refraction, and perfect lensing. Their response, however, tends to depend strongly on resonant effects, thereby limiting the application bandwidth. Driscoll et al. (p. 1518 , published online 20 August) combine a split ring resonator array with the phase change material, VO 2 , to form a metamaterial in which the response can be tuned. The heat-induced phase change of VO 2 from an insulator to a metal alters the response of split-ring resonator, and, because it displays a hysteresis, the device can retain a “memory” of the induced change. The results may lead to a flexible method for achieving metamaterials operating over a wide bandwidth and to novel switching applications.

We report the experimental demonstration of an electrically driven, single-mode, low threshold current (approximately 260 microA) photonic band gap laser operating at room temperature. The electrical current pulse is injected through a sub-micrometer-sized semiconductor wire at the center of the mode with minimal degradation of the quality factor. The actual mode of interest operates in a nondegenerate monopole mode, as evidenced through the comparison of the measurement with the computation based on the actual fabricated structural parameters. As a small step toward a thresholdless laser or a single photon source, this wavelength-size photonic crystal laser may be of interest to photonic crystals, cavity quantum electrodynamics, and quantum information communities.

Abstract The discovery of drivers of cancer has traditionally focused on protein-coding genes 1–4 . Here we present analyses of driver point mutations and structural variants in non-coding regions across 2,658 genomes from the Pan-Cancer Analysis of Whole Genomes (PCAWG) Consortium 5 of the International Cancer Genome Consortium (ICGC) and The Cancer Genome Atlas (TCGA). For point mutations, we developed a statistically rigorous strategy for combining significance levels from multiple methods of driver discovery that overcomes the limitations of individual methods. For structural variants, we present two methods of driver discovery, and identify regions that are significantly affected by recurrent breakpoints and recurrent somatic juxtapositions. Our analyses confirm previously reported drivers 6,7 , raise doubts about others and identify novel candidates, including point mutations in the 5′ region of TP53 , in the 3′ untranslated regions of NFKBIZ and TOB1 , focal deletions in BRD4 and rearrangements in the loci of AKR1C genes. We show that although point mutations and structural variants that drive cancer are less frequent in non-coding genes and regulatory sequences than in protein-coding genes, additional examples of these drivers will be found as more cancer genomes become available.

In the same way businesses use big data to pursue profits, governments use it to promote the public good.