The evolutionary history of 2,658 cancers

Gerstung, M.; Jolly, Clemency; Leshchiner, I.; Dentro, S.; Gonzalez, Santiago; Mitchell, T.; Rubanova, Yulia; Anur, Pavana; Yu, K.; Tarabichi, M.; Deshwar, A.; Wintersinger, J.; Kleinheinz, K.; Vázquez-García, I.; Haase, K.; Jerman, L.; Sengupta, Subhajit; Macintyre, G.; Malikić, S.; Donmez, Nilgun; Livitz, D.; Cmero, Marek; Demeulemeester, J.; Schumacher, S.; Fan, Yu; Yao, Xiaotong; Lee, Juhee; Schlesner, M.; Boutros, P.; Bowtell, D.; Zhu, Hongtu; Getz, G.; Imieliński, M.; Beroukhim, R.; Sahinalp, S.; Ji, Yuan; Peifer, M.; Markowetz, F.; Mustonen, V.; Yuan, Ke; Wang, Wenyi; Morris, Q.; J. Adams, D.; J. Campbell, Peter; Cao, S.; Christie, E.; Cun, Yupeng; Dawson, K.; M. Drews, Ruben; Eils, R.; Fittall, M.; Garsed, D.; Ha, G.; Lee-Six, H.; Martincorena, I.; Oesper, Layla; Peto, Myron; J. Raphael, Benjamin; Rosebrock, Daniel; Salcedo, A.; Shi, Ruian; Shin, S.; Spiro, O.; Stein, Lincoln; Vembu, Shankar; A. Wheeler, David; Yang, Tsun-Po; Spellman, P.; Wedge, D.; Loo, P.

doi:10.1038/s41586-019-1907-7

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The evolutionary history of 2,658 cancers

Shared by NobleBlocks on Jul 11, 2017 • 12:00 AM UTC

Authors:

M. Gerstung

Clemency Jolly

I. Leshchiner

Abstract

Cancer develops through a process of somatic evolution1,2. Sequencing data from a single biopsy represent a snapshot of this process that can reveal the timing of specific genomic aberrations and the changing influence of mutational processes3. Here, by whole-genome sequencing analysis of 2,658 canc...

Subject

Medicine

Biology

Computer Science

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