Hospital Domingo Funes

BACKGROUND: Soil-transmitted helminth (STH) infections are a public health problem in resource-limited settings worldwide. Chronic STH infection impairs optimum learning and productivity, contributing to the perpetuation of the poverty-disease cycle. Regular massive drug administration (MDA) is the cardinal recommendation for its control; along with water, sanitation and hygiene (WASH) interventions. The impact of joint WASH interventions on STH infections has been reported; studies on the independent effect of WASH components are needed to contribute with the improvement of current recommendations for the control of STH. The aim of this study is to assess the association of lacking access to water and sanitation with STH infections, taking into account the differences in route of infection among species and the availability of adequate water and sanitation at home. METHODS AND FINDINGS: Cross-sectional study, conducted in Salta province, Argentina. During a deworming program that enrolled 6957 individuals; 771 were randomly selected for stool/serum sampling for parasitological and serological diagnosis of STH. Bivariate stratified analysis was performed to explore significant correlations between risk factors and STH infections grouped by mechanism of entry as skin-penetrators (hookworms and Strongyloides stercoralis) vs. orally-ingested (Ascaris lumbricoides and Trichuris trichiura). After controlling for potential confounders, unimproved sanitation was significantly associated with increased odds of infection of skin-penetrators (adjusted odds ratio [aOR] = 3.9; 95% CI: 2.6-5.9). Unimproved drinking water was significantly associated with increased odds of infection of orally-ingested (aOR = 2.2; 95% CI: 1.3-3.7). CONCLUSIONS: Lack of safe water and proper sanitation pose a risk of STH infections that is distinct according to the route of entry to the human host used by each of the STH species. Interventions aimed to improve water and sanitation access should be highlighted in the recommendations for the control of STH.

BACKGROUND: Dextrose injection is reported to improve knee osteoarthritis (KOA)-related clinical outcomes, but its effect on articular cartilage is unknown. A chondrogenic effect of dextrose injection has been proposed. OBJECTIVE: To assess biological and clinical effects of intra-articular hypertonic dextrose injections (prolotherapy) in painful KOA. DESIGN: Case series with blinded arthroscopic evaluation before and after treatment. SETTING: Physical medicine and day surgery practice. PARTICIPANTS: Symptomatic KOA for at least 6 months, arthroscopy-confirmed medial compartment exposed subchondral bone, and temporary pain relief with intra-articular lidocaine injection. INTERVENTION: Four to 6 monthly 10-mL intra-articular injections with 12.5% dextrose. MAIN OUTCOME MEASURES: Visual cartilage growth assessment of 9 standardized medial condyle zones in each of 6 participants by 3 arthroscopy readers masked to pre-/postinjection status (total 54 zones evaluated per reader); biopsy of a cartilage growth area posttreatment, evaluated using hematoxylin and eosin and Safranin-O stains, quantitative polarized light microscopy, and immunohistologic cartilage typing; self-reported knee specific quality of life using the Western Ontario McMaster University Osteoarthritis Index (WOMAC, 0-100 points). RESULTS: Six participants (1 female and 5 male) with median age of 71 years, WOMAC composite score of 57.5 points, and a 9-year pain duration received a median of 6 dextrose injections and follow-up arthroscopy at 7.75 months (range 4.5-9.5 months). In 19 of 54 zone comparisons, all 3 readers agreed that the posttreatment zone showed cartilage growth compared with the pretreatment zone. Biopsy specimens showed metabolically active cartilage with variable cellular organization, fiber parallelism, and cartilage typing patterns consistent with fibro- and hyaline-like cartilage. Compared with baseline status, the median WOMAC score improved 13 points (P = .013). Self-limited soreness after methylene blue instillation was noted. CONCLUSIONS: Positive clinical and chondrogenic effects were seen after prolotherapy with hypertonic dextrose injection in participants with symptomatic grade IV KOA, suggesting disease-modifying effects and the need for confirmation in controlled studies. Minimally invasive arthroscopy (single-compartment, single-portal) enabled collection of robust intra-articular data. LEVEL OF EVIDENCE: IV.

BACKGROUND: Recommendations for soil-transmitted helminth (STH) control give a key role to deworming of school and pre-school age children with albendazole or mebendazole; which might be insufficient to achieve adequate control, particularly against Strongyloides stercoralis. The impact of preventive chemotherapy (PC) against STH morbidity is still incompletely understood. The aim of this study was to assess the effectiveness of a community-based program with albendazole and ivermectin in a high transmission setting for S. stercoralis and hookworm. METHODOLOGY: Community-based pragmatic trial conducted in Tartagal, Argentina; from 2012 to 2015. Six communities (5070 people) were enrolled for community-based PC with albendazole and ivermectin. Two communities (2721 people) were re-treated for second and third rounds. STH prevalence, anemia and malnutrition were explored through consecutive surveys. Anthropometric assessment of children, stool analysis, complete blood count and NIE-ELISA serology for S. stercoralis were performed. PRINCIPAL FINDINGS: STH infection was associated with anemia and stunting in the baseline survey that included all communities and showed a STH prevalence of 47.6% (almost exclusively hookworm and S. stercoralis). Among communities with multiple interventions, STH prevalence decreased from 62% to 23% (p<0.001) after the first PC; anemia also diminished from 52% to 12% (p<0.001). After two interventions S. stercoralis seroprevalence declined, from 51% to 14% (p<0.001) and stunting prevalence decreased, from 19% to 12% (p = 0.009). CONCLUSIONS: Hookworm' infections are associated with anemia in the general population and nutritional impairment in children. S. stercoralis is also associated with anemia. Community-based deworming with albendazole and ivermectin is effective for the reduction of STH prevalence and morbidity in communities with high prevalence of hookworm and S. stercoralis.

Introduction: Critically ill children in the pediatric intensive care unit (PICU) are at high risk for developing nutritional deficiencies and undernutrition is known to be a risk factor for morbidity and mortality. Malnutrition represents a continuous spectrum ranging from marginal nutrient status to severe metabolic and functional alterations and this in turn, affects clinical outcome. Objectives: The aim of the study was to assess nutritional status of critically ill children admitted to the PICU and its association to clinical outcomes. Methods: Critically ill children age 6 months to 18 years were prospectively enrolled on PICU admission. Nutritional status was assessed by weight for age (WFA: underweight), weight for height (WFH: wasting), height for age (HFA: stunting) z-scores and mid upper arm circumference (MUAC: wasting) according to the WHO. (1,2) Malnutrition was defined as mild, moderate, and severe if z-scores were > -1, > -2, and > -3, respectively. Hospital and PICU length of stay (LOS), duration of mechanical ventilation (MV), and risk of mortality (ROM) by the Pediatric Index of Mortality 2 (PIM2) were obtained. Sensitivity and specificity of the MUAC to identify children with wasting (WFH) were calculated. Results: Two hundred and fifty children (136 males), aged 81 months (23-167; median (25-75 th IQR)), were prospectively included in the study. The hospital LOS was 8 (4-16) days; PICU LOS: 2 (1-4) days; duration of MV, 0 (0-1.5) days; PIM2 ROM 2.61 0.25 %. WFA, WFH, and HFA z-scores of -0.48 0.14; 0.19 0.13; and -0.95 0.13 respectively; MUAC, 16.3 0.18 cm (6 to 59 months, n = 108); 24.2 0.46 cm (5 to 18 years, n = 142). The prevalence of underweight, wasting and stunting was 26.4 %, 19.6 %, and 44.4 % respectively. The sensitivity and specificity for MUAC vs. WFH to identify wasting was: 34.5 % (20.3-50.6; 95 % CI) and 95.5 % (91.8-97.9), respectively. Values are mean SE.

INTRODUCTION: Nosocomial pathogens have become a priority issue for public health, since they are responsible for increased morbidity and mortality in hospitalized patients and the development of multi-resistant microorganisms, as well. Recent studies found strong evidence that airborne transmission plays a key role in many nosocomial infections. Thus, we aim to develop a QuEChER methodology for the characterization of airborne microbial levels, analyzing potential variables that modify the air microbiological load. METHODOLOGY: Particulate matter levels and suspended and settled bioaerosols were determined simultaneously employing optical sensors, Harvard impactors and settle plates, respectively. Environmental variables were also measured at different sites during different working shifts and seasons. RESULTS: We found a straightforward relationship between airborne particles, air exchange rates, and people influx. Levels of suspended microorganisms were related to fine particulate matter concentration, CO2 and ambient temperature. A positive linear relationship (R2 = 0.9356) was also found between fine particulate matter and CO2 levels and air microbial load. CONCLUSION: The QuEChER methodology is an effective methodology that could be used to improve the surveillance of nosocomial pathogens in developing countries hospitals where air quality is scarcely controlled.

OBJECTIVE: To determine the operational cost of a hospital's surgical unit, compare those results with standards, and determine the incidence of the costs; to produce an effective methodology for this purpose that can be applied to all kinds of medical units using any low-cost widely available computer database system, with that methodology being utilized for ongoing management control. METHODS: This study was carried out in 1999 in the Orthopedics and Traumatology Unit of the "Domingo Funes" Public Hospital, in the province of Córdoba, Argentina. Of the 817 patients who underwent diagnostic or therapeutic procedures in that unit during the year, we selected the 154 of them who were hospitalized and required surgical or instrumental procedures. The study used the tracer event method described by Kessner. Through a consensus process, medical specialists and health economists selected and defined these indicators, which were categorized in relation to their complexity (high, medium, limited, or none). Direct and indirect costs were assessed in order to study their contribution to total cost. Total cost was estimated using nine variables that were applied to the different tracer events. RESULTS: The largest portion of total cost, both real and standard, was based on the "bed-day" variable. Of this bed-day cost for all tracer events, 51.2% was due to an indirect cost of "social hospitalization" (keeping patients hospitalized for such reasons as transportation difficulties or delays in receiving requested medical supplies) and 48.8% to a direct cost of true therapeutic hospitalization. This bed-day cost was 117% higher for the real costs as compared to the standard costs. The indirect costs of social hospitalization and of therapeutic supplies made up nearly half of the total real cost. Excluding the indirect costs, the real cost of all the tracer events exceeded the standard cost by only 6.4%. Including the indirect costs of social hospitalization and of therapeutic supplies, the real cost exceeded the standard cost by 39.8%. The amount spent on medical staff and support personnel represented just 11.5% of the total cost. DISCUSSION: Suggestions are provided in various areas, including solutions for the high cost of social hospitalization and therapeutic supplies, the cost-control benefits of creating protocols for procedures and treatments, and the rational utilization of technology in order to improve efficiency and reduce risks. The wider application of this procedure is recommended for cost-management control in all hospital units carrying out surgery or other medical procedures.

We analyzed contemporary oral narratives about birds collected among rural inhabitants of northern Córdoba in order to discuss alternative ways of interpreting human–bird relationships. A total of 150 stories were analyzed in terms of their typology, representativeness, ecological and social aspects expressed in them and functionality, as well as the utilitarian value of the species. In addition, we analyzed alternative ways of interpreting and classifying the augural role of birds. We propose that the narrative shows animistic traits (continuity between animals and humans) according to which the augural role of birds can be interpreted as a non-verbal communicative vestige between humans and avifauna. The mentioned birds (29 species) were grouped into 15 taxonomic orders and 22 families. The narratives classified as knowledge/practices made up 79.3% of the total of the non-narrative stories, while 19.5% corresponded to narrative stories. Ethological knowledges were among the best represented. Non-narrative stories referred to ecological knowledge about birds and practices related to their use as food. Myths, legends and anecdotes were the best represented narrative stories and, in general, they worked as transmitters of norms of social behaviours. The “ornithoauguries” can be explained as the interpretation of ecological knowledge of birds, as the elucidation of an intraspecific zoosemiotic message recoded by humans, or as an intersubjective communication between beings, as it happens in indigenous societies. Finally, we discuss the interpretation of these auguries in mestizo societies such as the creoles of northern Córdoba, which have indigenous and European influences.

Introduction: Microcephaly and brain abnormalities may be due to multiple etiologies, one of them is the congenital infection by Zika virus (ZIKV). From 2016 to the present, there has been a series of ZIKV outbreaks in Argentina. Methods: National Network of Congenital Anomalies (RENAC) and the National Institute of Viral Diseases (INEVH), under the National Administration of Laboratories and Health Institutes “Carlos Malbrán” (ANLIS), carry out the intensified surveillance of newborns with microcephaly and brain abnormalities. This article presents the clinical characteristics and laboratory testof patients detected with congenital infection by ZIKV between April 2016 to March 2018, Results: 10 cases with embryopathy were detected, six autochthonous and four imported; in two cases, the mothers were asymptomatic during pregnancy; all the cases presented microcephaly and cranial facial disproportion, ventriculomegaly in seven cases and in six cerebral calcifications. The diagnosis of congenital infection by Zika in the newborn was made by antigen-specific Immunoglobulin M (MAC-ELISA) and plaque-reduction neutralization test (PRNT90 ). PCR was negative in all cases. Conclusion: the patients presented clinical features that were consistent with those reported in other countries. The need for serological studies that allow confirmation is emphasized, ruling out cross-reactivity with other Flaviviruses.

"Objetivos. El trasplante celular para la regeneración del miocardio está limitado por la escasa viabilidad del injerto y la baja retención celular. En la miocardiopatía isquémica la matriz extracelular está profundamente alterada, por consiguiente, sería importante asociar un procedimiento para regenerar las células miocárdicas y restaurar la función de la matriz extracelular. En este estudio clínico, fue evaluada la terapia celular intrainfarto asociada a una matriz de colágeno sembrada con células e implantada sobre ventrículos infartados. Métodos. En 15 pacientes (54,2 ± 3,8 años de edad) que presentaban cicatrices miocárdicas postisquémicas en el ventrículo izquierdo (VI) y con indicación de cirugía de revascularización miocárdica, se implantaron, durante la operación, células de la médula ósea mononucleares autólogas (CMO) en la cicatriz. Se agregó sobre esa zona infartada una matriz de colágeno tipo I con el mismo número de CMO. Resultados. No hubo mortalidad ni eventos adversos relacionados (seguimiento 15 ± 4,2 meses). La clase funcional según la New York Heart Association (NYHA) mejoró de 2,3 ± 0,5 a 1,4 ± 0,3 (p=0,005). El volumen de fin de diástole del VI evolucionó de 142 ± 24 a 117 ± 21 mL (p=0,03), el tiempo de desaceleración del llenado del VI mejoró aumentando de 162 ± 7 mseg a 196 ± 8 mseg (p=0,01). El espesor del área cicatrizada progresó de 6 ± 1,4 a 9 ± 1,5 mm (p=0,005). La fracción de eyección (FE) mejoró de 25 ± 7 a 33 ± 5% (p=0,04). Conclusiones. La inyección intramiocárdica de células de médula ósea y la fijación simultánea de una matriz sembrada con progenitores celulares ( stem cells ) sobre el epicardio fue simple y sin complicaciones. La matriz de colágeno aumento el espesor de la zona del infarto con nuevos tejidos viables, limitando la dilatación ventricular y mejorando la función diastólica. Estos resultados positivos no pueden ser absolutamente relacionados a las células y la matriz, pues se asociaron puentes de revascularización coronaria. En conclusión, la ingeniería de tejidos puede extender las indicaciones y beneficios de la terapia con células madre en cardiología, convirtiéndose en un camino prometedor para la creación de un “miocardio bioartificial”."

"Introducción, La hidatidosis es una zoonosis producida por Echinococcus spp., el cual habita el intestino de algunos cánidos (perro), el humano es huésped intermediario accidental, pudiendo albergar uno o más quistes en diferentes localizaciones, principalmente el hígado y el pulmón. El tratamiento estándar de la hidatidosis hepática ha sido históricamente quirúrgico, incluyendo procedimientos conservadores o radicales. El área de influencia del Hospital Provincial "Domingo Funes", Córdoba, Argentina, es considerada zona endémica. Material y métodos, Estudio retrospectivo y descriptivo que incluyó a 57 pacientes diagnosticados con hidatidosis hepática e intervenidos quirúrgicamente entre enero de 1985 y diciembre de 2009. Resultados, Del total de pacientes 50.9% fue del sexo femenino y la edad promedio fue de 53 años. La presentación clínica predominante fue el dolor en 56% y tumor palpable en 33.3%. En 93% de los casos se utilizó la ecografía como método de diagnóstico (sensibilidad de 100%). La velocidad de sedimentación globular se halló aumentada en 63%. Se realizó quistectomía total a 47.4% de los pacientes. La morbilidad operatoria fue de 29.8%. La mortalidad quirúrgica fue de 0%. El tiempo de hospitalización fue de 12 días en promedio. Conclusiones, El análisis clínico-epidemiológico constituye el pilar del diagnóstico, complementado por ecografía, tomografía y analítica sanguínea. Se sugiere la quistectomía total como primera opción quirúrgica, por su menor morbilidad y mortalidad y tiempo de hospitalización posquirúrgico, similar a lo informado en series similares."

OBJECTIVE: To present a simple and reliable method for the reconstruction of metacarpophalangeal joint by the cartilage transplantation of metatarsophalangeal joint. METHODS: From 1990, nine cases (11 sides) with traumatic metacarpophalangeal joint defect were treated by the autogenous cartilage transplantation of metatarsophalangeal joint followed by modified treatment. Appropriate biological mechanics was provided by internal fixation and collateral ligament repair. RESULTS: Followed up 6 months to 7 years, the range of joint motion was increased 35.1 degrees. The fusion of donor phalanges was fine, and the range of joint motion was decreased, even ankylosis after plastic operation, but no pain and no effect on walk. CONCLUSION: The key to successful operation is better matching of cartilage, reliable internal fixation, ligament reconstruction, thin cartilage and little bone of the donor, appropriate biological mechanical surroundings.

Alpha-1-antitrypsin deficiency (DAAT) is an autosomal codominant disorder that predisposes to chronic obstructive pulmonary disease (COPD) and liver disease.A plasma concentration below 50mg/dL is considered to represent a relevant deficiency.It is caused by inheritance of 2 severe deficiency alleles of the SERPINA-1 gene located on chr14.We report the identification of a novel <i>SERPINA-1</i> mutation in a patient with severe dyspnea.A 43 year-old woman from Argentina (Cordoba city) consulted in 2012 for a 2-year-progressive dyspnea.The thorax XR film and other studies showed air-trapping with a FEV1:49% and CAT:23.She has a history of 26 packs/year and has been chronically exposed to second hand smoking due to her job.She had no liver damage.Capillary zone electrophoresis showed a decrease of alpha1globulin band.AAT levels measured by nephelometry were 28 mg/dL (RV:83-199 mg/dL).AAT phenotype testing by isoelectric focusing electrophoresis revealed a MZ pattern.A targeted allele-specific AAT genotyping to the S and Z alleles was performed revealing that the patient was heterozygous for the Z allele.As the patient9s AAT concentration was lower than it would be expected for an individual with a MZ phenotype, we suspected that the patient had a rare allele.We found Glu342<b>G</b>AG→Lys<b>A</b>AG (Z allele heterozygous) in exon 5 the sequencing analysis but we also found a non-reported Leu30C<b>T</b>G→ArgC<b>G</b>G in one of the alleles in exon 2.To our knowledge, this mutation has not been previously reported.Her father and siblings were studied and showed neither AAT deficiency nor lung affection (only AAT dosage performed).The patient was finally diagnosed with COPD associated with AAT deficiency.

La cromomicosis o cromoblastomicosis es una micosis profunda localizada en piel y en tejido celular subcutáneo producida por hongos dermatináceos (presencia de pigmento melánico en las paredes de los micelos) que penetran por inoculación traumática. La especie de hongo Fonsecaea Pedrosoi es la más frecuente y aparece en zonas tropicales y subtropicales, en trabajadores de la tierra (agricultura, minería, etc.).Presentamos el caso de un varón de 70 años, trabajador rural, con una lesión supurativa de piel en zona inguinal izquierda, de más de un año de evolución. Se realizó biopsia excisional. Macroscópicamente se observó un losange de piel con una placa de aspecto verrugoso de 1,2 x 0,8 cm de color violáceo con puntos hemorrágicos. El examen histopatológico reveló un cuadro de dermatitis granulomatosa supurativa con compromiso dérmico. Los granulomas fueron de diferentes tamaños, algunos iniciales otros microbscedados. Contenían células epitelioides, células gigantes multinucleadas e infiltrado mixto a predominio de neutrófilos, todos ellos en relación a la presencia de hongos denominados cuerpos escleróticos de Medlar o “peniques de cobre” por su aspecto bilaminado y color pardo, que midieron 4 a 6 µm de diámetro. La coloración de PAS reforzó la coloración propia de las membranas. Los granulomas se acompañaron de hiperplasia pseudoepiteliomatosa, hiperqueratosis y fibrosis dérmica. La cromomicosis debe considerarse entre los diagnósticos diferenciales de las lesiones verruciformes de piel, especialmente en zonas endémicas. La biopsia y coloración con H&amp;E es suficiente para el diagnóstico definitivo. Debe tenerse en cuenta que las lesiones pueden ser múltiples, por autoinoculación con el rascado o por diseminación linfática, pueden también presentar largo tiempo de evolución y alcanzar gran tamaño que produzcan linfedema.

Strategies for the prevention of arboviral diseases transmitted by Aedes aegypti have traditionally focused on vector control. This remains the same to this day, despite a lack of documented evidence on its efficacy due to a lack of coverage and sustainability. The continuous growth of urban areas and generally unplanned urbanization, which favor the presence of Ae. aegypti, demand resources, both material and human, as well as logistics to effectively lower the population’s risk of infection. These considerations have motivated the development of tools to identify areas with a recurrent concentration of arboviral cases during an outbreak to be able to prioritize preventive actions and optimize available resources. This study explores the existence of spatial patterns of dengue incidence in the locality of Tartagal, in northeastern Argentina, during the outbreaks that occurred between 2010 and 2020. Approximately half (50.8%) of the cases recorded during this period were concentrated in 35.9% of the urban area. Additionally, an important overlap was found between hotspot areas of dengue and chikungunya (Kendall’s W = 0.92; p-value &lt; 0.001) during the 2016 outbreak. Moreover, 65.9% of the cases recorded in 2022 were geolocalized within the hotspot areas detected between 2010 and 2020. These results can be used to generate a risk map to implement timely preventive control strategies that prioritize these areas to reduce their vulnerability while optimizing the available resources and increasing the scope of action.

Alpha-1-antitrypsin deficiency (AATD) is a genetic disorder that predisposes to COPD and liver disease. A plasma concentration &lt;50 mg/dL is considered a relevant deficiency. It is caused by inheritance of deficiency alleles such as Z and S allele. Besides these, rare alleles causing deficiency have been described but are usually misdetected with current tests. Our aim was to assess the frequencies of rare SERPINA1 mutations in Argentinean patients that came to our Hospital and were referred for AATD diagnostics due to chronic respiratory disorders from 2013–16. AAT levels were measured by nephelometry. Phenotype testing by isoelectric focusing electrophoresis (IEF) and genotyping by targeted allele-specific PCR for S and Z alleles. Full-gene sequencing was performed with GenomeLab (ex.2-5). A total of 217 patients had an AAT serum concentration &lt;100 mg/dL; 144 (66.4%) showed discordant pheno/geno results considering the low serum AAT levels. Some of the patients were retrospectively analyzed by direct sequencing analysis (most of the patients recruited didn´t referred to the laboratory due to logistic difficulties) and the following pathogenic variants were found: Mmalton was the most frequent in our population and was found in heterozygous state in 6 cases (5Mmalton-Z, 1Mmalton-S); Mprocida in 1 case of an Mprocida carrier and 1 case of a non-reported M-like variant (c.162T&gt;C, L30R) compound heterozygote with Z allele. Rare mutations not detected with current allele-specific testing and/or IEF underlie a substantial proportion of genetic AATD. Full-gene sequencing has the ability to improve accuracy in the diagnosis of AATD and solve the discordances of dosage and pheno/geno.

INTRODUCTION: Hereditary nonpolyposis colorectal cancer (HNPCC), also known as Lynch syndrome, represents 5% to 7% of colorectal cancers. It is an autosomal dominant inherited disorder characterized by an early onset of colorectal tumors, predominantly proximal, and multiple and microsatellite instability. We used the Amsterdam II criteria for its identification. OBJECTIVE: To analyze the case of a patient with a family history of malignant colorectal tumors at an early age of onset. CASE REPORT: A 40-year-old woman, from Valle de Punilla, Cordoba, Argentina, with no previous medical history, complained of mild changes in her bowel habits and was admitted to the general surgery department with the radiographic diagnosis of a tumor in the hepatic flexure of the colon. She underwent a right hemicolectomy for a Dukes B stenosing tumor (T3N0M0, stage IIa). CONCLUSION: In this report, we present the case of a woman with HNPCC who met the Amsterdam II criteria II. Family members who meet these criteria should be screened for the mutation in MMR genes. As genetic tests are not routinely available, an annual colonoscopic surveillance of all asymptomatic relatives older than 25 to 30 years old who meet the criteria is recommended, regardless of the availability and/or the outcome of genetic testing.

Introducción: El estudio imagenológico de las características morfométricas de la articulación de la cadera en una muestra de casos asintomáticos, reviste importancia para comprender variantes de normalidad.Material y método: Estudio retrospectivo sobre un archivo de tomografías computadas solicitadas por patologías abdomino-pélvicas, de ambos sexos con edades entre 18 y 45 años, ortopédicamente sanos. Se realizó una medición digital de la versión acetabular. Las variables consideradas y analizadas con estadística descriptiva fueron edad, sexo y versión acetabular.Resultados: Se incluyeron 165 pelvis, 102 masculinas (61,9%) y 63 femeninas (38,1%). La edad media de la cohorte fue de 36,4 años. La versión fue positiva (anteversión) en 163 casos, con una media masculina de 17,1° ± 2,7° (p <0,03) y femenina de 19,8° ± 3,9° (p <0,01). Dos pelvis masculinas tenían retroversión (1,2%). La diferencia de versión contralateral promedio fue de 1,15° ± 2,2°.Conclusión: El acetábulo femenino tiene una anteversión promedio mayor que el masculino. Es frecuente encontrar anteversión acetabular contralateral diferente. La prevalencia de retroversión en una muestra adulta joven asintomática es baja.