Institut de Recherche Interdisciplinaire en Sciences Sociales

The European Collaborative on Personalized Early Detection and Prevention of Breast Cancer (ENVISION) brings together several international research consortia working on different aspects of the personalized early detection and prevention of breast cancer. In a consensus conference held in 2019, the members of this network identified research areas requiring development to enable evidence-based personalized interventions that might improve the benefits and reduce the harms of existing breast cancer screening and prevention programmes. The priority areas identified were: 1) breast cancer subtype-specific risk assessment tools applicable to women of all ancestries; 2) intermediate surrogate markers of response to preventive measures; 3) novel non-surgical preventive measures to reduce the incidence of breast cancer of poor prognosis; and 4) hybrid effectiveness-implementation research combined with modelling studies to evaluate the long-term population outcomes of risk-based early detection strategies. The implementation of such programmes would require health-care systems to be open to learning and adapting, the engagement of a diverse range of stakeholders and tailoring to societal norms and values, while also addressing the ethical and legal issues. In this Consensus Statement, we discuss the current state of breast cancer risk prediction, risk-stratified prevention and early detection strategies, and their implementation. Throughout, we highlight priorities for advancing each of these areas.

The witness has become a key figure of our time, whether as the survivor testifying to what he has lived through or as the third party telling what he has seen or heard. Publicly bearing witness of suffering and injustice is precisely what departs the first (International Red Cross) and second (Doctors without Borders, Doctors of the World) ages of humanitarianism. Based on an etymological inquiry of the word in Greek and Latin and on an ethnographical investigation into the production of documents on the Israeli–Palestinian conflict, this analysis of the politics of testimony shows how the humanitarian agents define the legitimate manner to tell the world the “victims' truth.” In particular, the increasing presence of psychiatrists and psychologists on the field introduces a new vision in which trauma appears less as a clinical category than as a political argument. This process of subjectification of Palestinians but also of Israelis as victims, which institutes their experience and condition as shared, leaves aside both the individual and collective histories of the subjects.

Dual oxidases were initially identified as NADPH oxidases producing H(2)O(2) necessary for thyroid hormone biosynthesis. The crucial role of Duox2 has been demonstrated in patients suffering from partial iodide organification defect caused by bi-allelic mutations in the DUOX2 gene. However, the Duox1 function in thyroid remains elusive. We optimized a functional assay by co-expressing Duox1 or Duox2 with their respective maturation factors, DuoxA1 and DuoxA2, to compare their intrinsic enzymatic activities under stimulation of the major signaling pathways active in the thyroid in relation to their membrane expression. We showed that basal activity of both Duox isoenzymes depends on calcium and functional EF-hand motifs. However, the two oxidases are differentially regulated by activation of intracellular signaling cascades. Duox1 but not Duox2 activity is stimulated by forskolin (EC(50) = 0.1 microm) via protein kinase A-mediated Duox1 phosphorylation on serine 955. In contrast, phorbol esters induce Duox2 phosphorylation via protein kinase C activation associated with high H(2)O(2) generation (phorbol 12-myristate 13-acetate EC(50) = 0.8 nm). These results were confirmed in human thyroid cells, suggesting that Duox1 is also involved in thyroid hormonogenesis. Our data provide, for the first time, detailed insights into the mechanisms controlling the activation of Duox1-2 proteins and reveal additional phosphorylation-mediated regulation.

DNA double-strand breaks (DSBs) are considered as one of the primary causes of cancer but their induction by hydrogen peroxide (H(2)O(2)) is still controversial. In this work, we studied whether the high levels of H(2)O(2) produced in the thyroid to oxidize iodide could induce DNA modifications. Scores of DNA damage, in terms of strand breaks, were obtained by comet assay (alkaline condition for single-strand breaks (SSBs) and neutral condition for DSBs). We demonstrated that in a rat thyroid cell line (PCCl3), non-lethal concentrations of H(2)O(2) (0.1-0.5 mmol/l) as well as irradiation (1-10 Gy) provoked a large number of SSBs ( approximately 2-3 times control DNA damage values) but also high levels of DSBs (1.2-2.3 times control DNA damage values). We confirmed the generation of DSBs in this cell line and also in human thyroid in primary culture and in pig thyroid slices by measuring phosphorylation of histone H2AX. L-Buthionine-sulfoximine, an agent that depletes cells of glutathione, decreased the threshold to observe H(2)O(2)-induced DNA damage. Moreover, we showed that DNA breaks induced by H(2)O(2) were more slowly repaired than those induced by irradiation. In conclusion, H(2)O(2) causes SSBs and DSBs in thyroid cells. DSBs are produced in amounts comparable with those observed after irradiation but with a slower repair. These data support the hypothesis that the generation of H(2)O(2) in thyroid could also play a role in mutagenesis particularly in the case of antioxidant defense deficiency.

Ces travaux constituent une enquête anthropologique sur les ressorts du capitalisme contemporain. Ils portent un regard critique sur les formes du capital, la théorie de la valeur, l'analyse financière ou la théorie des marchés efficients.

<b>Introduction:</b> it has been suggested that sarcoidosis could be associated with exposure to inorganic particles (Newman LS Curr Opin All Clin Immunol 2012; 12:145-50, Vincent M et al Am J Ind Med 2015; 58:S31-8). <b>Objectives:</b> in order to test this hypothesis the Minasarc study was designed to evaluate the mineral exposome by a specific questionnaire (SQ) and a mineralogical analysis performed on BALs by optical and electron microscopy in patients and healthy volunteers (HV). We present here the results obtained by the SQ which can be considered as a tool for global assessment of the “whole life” exposure to inorganic particles in occupational and environmental contexts. <b>Methods:</b> The study was performed on 20 patients with sarcoidosis and 20 HV. Every HV was matched to a patient by sex, age and smoking habit. The SQ was calibrated with a representative sample of the French population (n=825) in the ELIPSSilice survey (ANR-10-Eqpx-19-01) and the result was expressed as a “dust score”. Scores were compared by a Wilcoxon signed-rank test<b>.</b> <b>Results:</b> The “dust score<b>”</b> was found significantly higher in patients with sarcoidosis than in HV (p=0,036; Wilcoxon signed-rank test). Moreover we found a significant overrepresentation of people exposed to building activities among the cases. However this remains to be assessed on a larger series. <b>Conclusion:</b> The SQ demonstrated a significantly higher level of exposure to inorganic dusts in patients with sarcoidosis compared to HV. Such preliminary results encourage 1) to study the association between sarcoidosis and inorganic dust exposure and 2) to submit routinely this exposure questionnaire to every patient with a granulomatous disease.

Personal protection equipment (PPE) holds a privileged position in safety interventions in many countries, despite the fact that they should only be used as a last resort. This is even more paradoxical because many concerns have arisen as to their actual effectiveness under working conditions and their ability to provide the protection attributed to them by certain occupational safety strategies and marketing authorisation procedures. Are these concerns justified? This article is intended to provide an update on what we know of the issue based on a critical analysis of the literature to date. Analysis focuses on the assessment of the effectiveness of coveralls used to protect from plant protection products in OECD countries. All forms of assessment were retained: discussion of the observed effectiveness of PPE in relation to the underlying assumptions of marketing authorisation procedures, laboratory tests of equipment, practical field tests in which PPE-wearing practices were controlled and uncontrolled, analyses of the efficiency of preventive instructions based on wearing such coveralls. Findings show that recommending the use of PPE is key to the granting of marketing authorisation. Some dangerous products only get marketing authorisation because it is assumed that wearing PPE will considerably limit exposure. They would be banned if it were not for this assumption of protection. However the actual effectiveness of PPE in working conditions may be over-estimated. In addition many factors (cost, availability, thermic and mechanical discomfort) may make instructions to wear PPE inapplicable. Advising the use of PPE does not always mean effective protection.

A sensitive and stable non-enzymatic sensing platform for<sc>d</sc>-glucose based on a reduced graphene oxide (rGO) matrix modified with Ni(OH)₂nanostructures was established.

Silicosis not a disease of the past. It is an irreversible, fibrotic lung disease specifically caused by exposure to respirable crystalline silica (RCS) dust. Over 20,000 incident cases of silicosis were identified in 2017 and millions of workers continue to be exposed to RCS. Identified case numbers are however a substantial underestimation due to deficiencies in reporting systems and occupational respiratory health surveillance programmes in many countries. Insecure workers, immigrants and workers in small businesses are at particular risk of more intense RCS exposure. Much of the focus of research and prevention activities has been on the mining sector. Hazardous RCS exposure however occurs in a wide range of occupational setting which receive less attention, in particular the construction industry. Recent outbreaks of silicosis associated with the fabrication of domestic kitchen benchtops from high-silica content artificial stone have been particularly notable because of the young age of affected workers, short duration of RCS exposure and often rapid disease progression. Developments in nanotechnology and hydraulic fracking provide further examples of how rapid changes in technology and industrial processes require governments to maintain constant vigilance to identify and control potential sources of RCS exposure. Despite countries around the world dealing with similar issues related to RCS exposure, there is an absence of sustained global public health response including lack of consensus of an occupational exposure limit that would provide protection to workers. Although there are complex challenges, global elimination of silicosis must remain the goal.

International audience

Interfacing nanowires and living cells is highly interesting in various fields including biomedical implants, biosensors or drug delivery. Vertically aligned silicon nanowire (SiNW) arrays prepared by the stain etching technique were investigated in this study. Chemical modification with octadecyltrichlorosilane (OTS) led to the formation of superhydrophobic SiNW surface with a contact angle around 160°. A micropatterned superhydrophilic/superhydrophobic SiNW surface was fabricated using standard optical lithography techniques. Here we report on Chinese Hamster Ovary K1 (CHO) cell culture on patterned superhydrophilic/superhydrophobic silicon nanowire surfaces. It was found that the cells adhered selectively to the superhydrophilic regions while cell adhesion was almost completely suppressed on the superhydrophobic surface. Transmission electron microscopy analysis showed that the cell cytoplasmic projections penetrate the hydrophilic silicon nanowires layer and coat the nanowires, leading to an intimate surface contact and thus a strong adhesion. On the superhydrophobic surface, the cell cytoplasmic projections remained on the top of wires. The nonfouling of the superhydrophobic SiNW substrate was attributed to a stable Cassie–Baxter state, limiting the contact with the culture medium. Another interesting finding from this study is the corrosion of the superhydrophilic SiNW surface in phosphate-buffered saline (PBS) solution.

The paper reports on the simultaneous reduction/deposition of thin films of rGO/Cu NPs from an ethanol solution of GO and CuSO₄using EPD technique. The electrocatalytic properties of the electrode were exploited for non-enzymatic glucose sensing.

This essay offers a new approach for conceptualizing the environmental impact of chemicals production, consumption, disposal, and regulation. Environmental protection regimes tend to be highly segmented according to place, media, substance, and effect. Existing scholarship often reflects this same segmentation, by focusing on a locality, specific chemical, social movement, or regulatory body. In turn, as new environmental measures are introduced to deal with pollution and toxicity, they tend to focus on controlling future effects rather than dealing with the accumulated contamination from past industrial activity and waste. In chemical substances we encounter phenomena that are at the same time voluminous and miniscule, regulated yet unruly. Inspired by recent work on materiality and infrastructures, we focus on the concept of residues as both material and political entities. Following residues, we argue, helps us see how the past has been built into our chemical environments and regulatory systems, and why contaminants seem to always evade control.

International audience

The development of non-antibiotic based treatments against bacterial infections by Gram-negative uropathogenic E. coli is a complex task. New strategies to treat such infections are thus urgently needed. This report illustrates the development of pegylated reduced graphene oxide nanoparticles (rGO-PEG) and gold nanorods (Au NRs) coated with rGO-PEG (rGO-PEG-Au NRs) for the selective killing of uropathogenic E. coli UTI89. We took advantage of the excellent light absorption properties of rGO-PEG and Au NR particles in the near-infrared (NIR) region to photothermally kill Gram-negative pathogens up to 99% in 10 min by illumination of solutions containing the bacteria. The rGO-PEG-Au NRs demonstrated better photothermal efficiency towards E. coli than rGO-PEG. Targeted killing of E. coli UTI89 could be achieved with rGO-PEG-Au NRs functionalized with multimeric heptyl α-d-mannoside probes. This currently offers a unique biocompatible method for the ablation of pathogens with the opening of probably a new possibility for clinical treatments of patients with urinary infections.

This article examines the corpus of multinationals’ codes of conduct on CSR issues which has been collated by the ILO. Through lexical software analysis we identify three main points of reference in CSR codes of conduct: respect for ILO norms, discussion of the company’s relationship to society, and reinforcement of its internal discipline and organisation. Surprisingly, the issue of corporate responsibility itself constitutes a small part of the text of the codes. Their main targets are employees, who are charged with a dual task: to ensure the implementation of the principles stated in the codes, and to protect the assets of the company. In a reflexive dimension, codes of conduct help us to understand the key characteristics of the companies which made them.

On sait que le capitalisme au XXIe siècle est synonyme d’inégalités grandissantes entre les classes sociales. Ce que l’on sait moins, c’est que l’inégalité de richesse entre les hommes et les femmes augmente aussi, malgré des droits formellement égaux et la croyance selon laquelle, en accédant au marché du travail, les femmes auraient gagné leur autonomie. Pour comprendre pourquoi, il faut regarder ce qui se passe dans les familles, qui accumulent et transmettent le capital économique afin de consolider leur position sociale d’une génération à la suivante. Conjointes et conjoints, frères et sœurs, pères et mères n’occupent pas les mêmes positions dans les stratégies familiales de reproduction, et n’en tirent pas les mêmes bénéfices. Fruit de vingt ans de recherches, ce livre montre que le capital a un genre.Céline Bessière et Sibylle Gollac enquêtent sur les calculs, les partages et les conflits qui ont lieu au moment des séparations conjugales et des héritages, avec le concours des professions du droit. Des mères isolées du mouvement des Gilets jaunes au divorce de Jeff et MacKenzie Bezos, des transmissions de petites entreprises à l’héritage de Johnny Hallyday, les mécanismes de contrôle et de distribution du capital varient selon les classes sociales, mais aboutissent toujours à la dépossession des femmes. Ce livre analyse ainsi comment la société de classes se reproduit grâce à l’appropriation masculine du capital.

Launched in 2019, the French Citizens' Convention for Climate (CCC) tasked 150 randomly chosen citizens with proposing fair and effective measures to fight climate change. This was to be fulfilled through an "innovative co-construction procedure", involving some unspecified external input alongside that from the citizens. Did inputs from the steering bodies undermine the citizens' accountability for the output? Did co-construction help the output resonate with the general public, as is expected from a citizens' assembly? To answer these questions, we build on our unique experience in observing the CCC proceedings and documenting them with qualitative and quantitative data. We find that the steering bodies' input, albeit significant, did not impair the citizens' agency, creativity, and freedom of choice. While succeeding in creating consensus among the citizens who were involved, this co-constructive approach, however, failed to generate significant support among the broader public. These results call for a strengthening of the commitment structure that determines how follow-up on the proposals from a citizens' assembly should be conducted.

ABSTRACT: This text aims to present the methodology of study of land-use conflicts performed in recent years by a multidisciplinary team, and to reveal the methods of survey and data collection, as well as the structure of the resulting database. We first define the scope of our study by providing a definition of these conflicts, of their characteristics and motives, of the ways they manifest themselves and of the actors involved (I). We then present the methodology we have used to identify conflicts; it is based on a spatial analysis and the combined use of different data collection methods including surveys conducted by experts, analyses of the regional daily press and of data from the administrative litigation courts (II). Finally we present the resulting Conflicts © data base, with its tables and nomenclatures, in which the data collected in different fields are reconciled and analyzed (III), before providing a few examples of how this method can be used to analyze case studies in developed and developing countries (IV). JEL CODES: D74; C83; K41.

The electrocatalytic properties of cobalt phthalocyanine modified reduced graphene oxide for peroxynitrite and hydrogen peroxide are investigated.