Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.

M Jhiang, S; E Sagartz, J; Tong, Q; Parker-Thornburg, J; C Capen, C; Y Cho, J; Xing, S; Ledent, C

doi:10.1210/endo.137.1.8536638

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Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.

Shared by NobleBlocks on Jan 1, 1996 • 12:00 AM UTC

Authors:

S M Jhiang

J E Sagartz

Q Tong

Abstract

The ret/PTC oncogene, a rearranged form of the ret proto-oncogene, has been found to be restricted to human papillary thyroid carcinomas. This report shows that transgenic mice with thyroid-targeted expression of the ret/PTC1 oncogene developed thyroid carcinomas with considerable similarities to hu...

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