Ministère des Armées

Unlike the past International Terrestrial Reference Frame (ITRF) versions where global long‐term solutions were combined, the ITRF2005 uses as input data time series (weekly from satellite techniques and 24‐h session‐wise from Very Long Baseline Interferometry) of station positions and daily Earth Orientation Parameters (EOPs). The advantage of using time series of station positions is that it allows to monitor station non‐linear motion and discontinuities and to examine the temporal behavior of the frame physical parameters, namely the origin and the scale. The ITRF2005 origin is defined in such a way that it has zero translations and translation rates with respect to the Earth center of mass, averaged by the Satellite Laser Ranging (SLR) time series spanning 13 years of observations. Its scale is defined by nullifying the scale and its rate with respect to the Very Long Baseline Interferometry (VLBI) time series spanning 26 years of observations. The ITRF2005 orientation (at epoch 2000.0) and its rate are aligned to the ITRF2000 using 70 stations of high geodetic quality. The estimated level of consistency of the ITRF2005 origin (at epoch 2000.0) and its rate with respect to the ITRF2000 is respectively 0.1, 0.8, 5.8 mm and 0.2, 0.1, 1.8 mm/yr along the X , Y and Z ‐axis. We estimate the formal errors on these components to be 0.3 mm and 0.3 mm/yr. We believe that this low level of agreement between the two frame origins is most probably due to the poor SLR network geometry and its degradation over time. The ITRF2005 combination involving 84 co‐location sites revealed a scale inconsistency of 1 ppb (6.3 mm at the equator), at epoch 2000.0, and 0.08 ppb/yr between the SLR and VLBI long‐term solutions as obtained by the stacking of their respective time series. Possible causes of this inconsistency may include the poor SLR and VLBI networks and their co‐locations, local tie uncertainties, systematic effects and possible inconsistent model corrections used in the data analysis of both techniques. For the first time of the ITRF history, the ITRF2005 rigorous combination provides self‐consistent series of EOPs, including Polar Motion from VLBI and satellite techniques and Universal Time and Length of Day from VLBI only. A velocity field of 152 sites with an error less than 1.5 mm/yr is used to estimate absolute rotation poles of 15 tectonic plates that are consistent with the ITRF2005 frame. This new absolute plate motion model supersedes and significantly improves that of the ITRF2000 which involved six major tectonic plates.

The outbreak of the Zika Virus (ZIKV) and its association with fetal abnormalities have raised worldwide concern. However, the cellular tropism and the mechanisms of ZIKV transmission to the fetus during early pregnancy are still largely unknown. Therefore, we ex vivo modeled the ZIKV transmission at the maternal-fetal interface using organ culture from first trimester pregnancy samples. Here, we provide evidence that ZIKV strain circulating in Brazil infects and damages tissue architecture of the maternal decidua basalis, the fetal placenta and umbilical cord. We also show that ZIKV replicates differentially in a wide range of maternal and fetal cells, including decidual fibroblasts and macrophages, trophoblasts, Hofbauer cells as well as umbilical cord mesenchymal stem cells. The striking cellular tropism of ZIKV and its cytopathic-induced tissue injury during the first trimester of pregnancy could provide an explanation for the irreversible congenital damages.

The review addresses the methods for depositing catalytic layers onto metallic structured substrates, specifically focusing on honeycomb monoliths and open-cell foams.

Sagem improvements made in the design, the process and the control of the HRG help to reach high performance while keeping the intrinsic simplicity of the Coriolis Vibrating Gyros family. Therefore it allows the HRG to challenge the laser gyros for strapdown inertial navigation. The simplicity derives from many patented innovations which lead to a very compact gyro with a very low number of components. The manufacturing takes advantage of this simplified design and of a new automatic tuning and balancing process which reduces sensitivities to mechanical environment. While using a Whole Angle mode of control which leads to very good scale factors, a new full digital electronics provides gain and phase accuracy at the level needed by the 0.01°/h class of bias performance. The paper explains these choices and presents the results obtained by the Sagem HRG during tests. Thanks to these characteristics, new applications are developed, especially when compactness, low consumption, reliability and maintenance free long term performance are needed as it is the case with Marine Gyrocompass or Marine Attitude and Heading Reference Systems. The architecture of the Sagem marine AHRS BlueNaute™ is presented and many test results are given, including those obtained on marine vessel.

BACKGROUND: There are limited data available on the economical burden of psoriasis and its impact on everyday life. OBJECTIVE: The aim of this study was to evaluate the impact of psoriasis on personal and professional life, and to evaluate the cost of psoriasis for the patient. METHODS: We performed a cross-sectional study in psoriasis patients. All patients aged >or=18 years with a diagnosis of plaque-psoriasis confirmed by a physician were included. A self-administered questionnaire evaluating everyday life was constructed with members of the French association of psoriasis patients. In addition, the Dermatology Life Quality Index (DLQI), Working Productivity and Activity Impairment and individual costs were assessed. RESULTS: A total of 590 patients completed the study. Mean age of the responders was 56 years. The mean DLQI score was 8.5 for patients with severe psoriasis vs. 6.4 for mild psoriasis. Global loss of productivity was 10.7% without significant difference according to the disease severity. Daily activities alteration was most important in patients with severe psoriasis. In this study, 36.8% of patients with severe psoriasis reported a negative impact on their professional life vs. 19.6% for patients with mild psoriasis (P = 0.002). Time devoted to phototherapy was on average 33 h/year/patient and the application of emollients took 25 h/year/patient; 47.3% of patients had a feeling to clean the house more often, in correlation with the severity of the disease. Mean out-of-pocket expenses for the disease was estimated to be 543 euro/year/patient. High impact of psoriasis on quality of life (DLQI >10), age <40 years and joint involvement were significantly associated with an increased risk of loss of work productivity. CONCLUSION: Psoriasis, particularly severe psoriasis, is a true burden for patients and impacts significantly everyday life and patient's economical resources.

Foot and mouth disease (FMD) is a highly contagious viral disease with high economic impact, representing a major threat for cloven-hooved mammals worldwide. Vaccines based on adjuvanted inactivated virus (iFMDV) induce effective protective immunity implicating antibody (Ab) responses. To reduce the biosafety constraints of the manufacturing process, a non-replicative human adenovirus type 5 vector encoding FMDV antigens (Ad5-FMDV) has been developed. Here we compared the immunogenicity of iFMDV and Ad5-FMDV with and without the ISA206VG emulsion-type adjuvant in sheep. Contrasted Ab responses were obtained: iFMDV induced the highest Ab levels, Ad5-FMDV the lowest ones, and ISA206VG increased the Ad5-FMDV-induced Ab responses to protective levels. Each vaccine generated heterogeneous Ab responses, with high and low responders, the latter being considered as obstacles to vaccine effectiveness. A transcriptomic study on total blood responses at 24 h post-vaccination revealed several blood gene module activities correlating with long-term Ab responses. Downmodulation of T cell modules' activities correlated with high responses to iFMDV and to Ad5-FMDV+ISA206VG vaccines as also found in other systems vaccinology studies in humans and sheep. The impact of cell cycle activity depended on the vaccine types, as it positively correlated with higher responses to iFMDV but negatively to non-adjuvanted Ad5-FMDV. Finally an elevated B cell activity at 24 h correlated with high Ab responses to the Ad5-FMDV+ISA206VG vaccine. This study provides insights into the early mechanisms driving the Ab response induced by different vaccine regimens including Ad5 vectors and points to T cell modules as early biomarker candidates of different vaccine-type efficacy across species.

BACKGROUND: School closure is a non-pharmaceutical intervention that was considered in many national pandemic plans developed prior to the start of the influenza A(H1N1)pdm09 pandemic, and received considerable attention during the event. Here, we retrospectively review and compare national and local experiences with school closures in several countries during the A(H1N1)pdm09 pandemic. Our intention is not to make a systematic review of country experiences; rather, it is to present the diversity of school closure experiences and provide examples from national and local perspectives. METHODS: Data were gathered during and following a meeting, organized by the European Centres for Disease Control, on school closures held in October 2010 in Stockholm, Sweden. A standard data collection form was developed and sent to all participants. The twelve participating countries and administrative regions (Bulgaria, China, France, Hong Kong Special Administrative Region (SAR), Italy, Japan, New Zealand, Serbia, South Africa, Thailand, United Kingdom, and United States) provided data. RESULTS: Our review highlights the very diverse national and local experiences on school closures during the A(H1N1)pdm09 pandemic. The processes including who was in charge of making recommendations and who was in charge of making the decision to close, the school-based control strategies, the extent of school closures, the public health tradition of responses and expectations on school closure varied greatly between countries. Our review also discusses the many challenges associated with the implementation of this intervention and makes recommendations for further practical work in this area. CONCLUSIONS: The single most important factor to explain differences observed between countries may have been the different public health practises and public expectations concerning school closures and influenza in the selected countries.

BACKGROUND: High-voltage overhead power lines (HVOLs) are a source of extremely low-frequency magnetic fields (ELF-MFs), which are classified as possible risk factors for childhood acute leukaemia (AL). The study was carried out to test the hypothesis of an increased AL incidence in children living close to HVOL of 225-400 kV (VHV-HVOL) and 63-150 kV (HV-HVOL). METHODS: The nationwide Geocap study included all the 2779 cases of childhood AL diagnosed in France over 2002-2007 and 30 000 contemporaneous population controls. The addresses at the time of inclusion were geocoded and precisely located around the whole HVOL network. RESULTS: Increased odds ratios (ORs) were observed for AL occurrence and living within 50 m of a VHV-HVOL (OR=1.7 (0.9-3.6)). In contrast, there was no association with living beyond that distance from a VHV-HVOL or within 50 m of a HV-HVOL. CONCLUSION: The present study, free from any participation bias, supports the previous international findings of an increase in AL incidence close to VHV-HVOL. In order to investigate for a potential role of ELF-MF in the results, ELF-MF at the residences close to HVOL are to be estimated, using models based on the annual current loads and local characteristics of the lines.

We survey algorithms for computing isogenies between elliptic curves defined over a field of characteristic either 0 or a large prime. We introduce a new algorithm that computes an isogeny of degree <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="script l"> <mml:semantics> <mml:mi> ℓ </mml:mi> <mml:annotation encoding="application/x-tex">\ell</mml:annotation> </mml:semantics> </mml:math> </inline-formula> ( <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="script l"> <mml:semantics> <mml:mi> ℓ </mml:mi> <mml:annotation encoding="application/x-tex">\ell</mml:annotation> </mml:semantics> </mml:math> </inline-formula> different from the characteristic) in time quasi-linear with respect to <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="script l"> <mml:semantics> <mml:mi> ℓ </mml:mi> <mml:annotation encoding="application/x-tex">\ell</mml:annotation> </mml:semantics> </mml:math> </inline-formula> . This is based in particular on fast algorithms for power series expansion of the Weierstrass <inline-formula content-type="math/mathml"> <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML" alttext="normal script upper P"> <mml:semantics> <mml:mi mathvariant="normal"> ℘ </mml:mi> <mml:annotation encoding="application/x-tex">\wp</mml:annotation> </mml:semantics> </mml:math> </inline-formula> -function and related functions.

Obesity is associated with a chronic low-grade inflammation that predisposes to insulin resistance and the development of type 2 diabetes. In this metabolic context, gastrointestinal (GI) candidiasis is common. We recently demonstrated that the PPARγ ligand rosiglitazone promotes the clearance of Candida albicans through the activation of alternative M2 macrophage polarization. Here, we evaluated the impact of high fat diet (HFD)-induced obesity and the effect of rosiglitazone (PPARγ ligand) or WY14643 (PPARα ligand) both on the phenotypic M1/M2 polarization of peritoneal and cecal tissue macrophages and on the outcome of GI candidiasis. We demonstrated that the peritoneal macrophages and the cell types present in the cecal tissue from HF fed mice present a M2b polarization (TNF-α(high), IL-10(high), MR, Dectin-1). Interestingly, rosiglitazone induces a phenotypic M2b-to-M2a (TNF-α(low), IL-10(low), MR(high), Dectin-1(high)) switch of peritoneal macrophages and of the cells present in the cecal tissue. The incapacity of WY14643 to switch this polarization toward M2a state, strongly suggests the specific involvement of PPARγ in this mechanism. We showed that in insulin resistant mice, M2b polarization of macrophages present on the site of infection is associated with an increased susceptibility to GI candidiasis, whereas M2a polarization after rosiglitazone treatment favours the GI fungal elimination independently of reduced blood glucose. In conclusion, our data demonstrate a dual benefit of PPARγ ligands because they promote mucosal defence mechanisms against GI candidiasis through M2a macrophage polarization while regulating blood glucose level.

Based on a model study, a new bis-cyclic monomer bearing a Diels–Alder adduct was synthesized. This monomer was polymerized with a diamine to yield a thermoresponsive polyhydroxyurethane (PHU). This PHU is remendable at around 100 °C by retro Diels–Alder reaction.

We recently showed that IL-13 or peroxisome proliferator activated receptor gamma (PPARgamma) ligands attenuate Candida albicans colonization of the gastrointestinal tract. Here, using a macrophage-specific Dectin-1 deficient mice model, we demonstrate that Dectin-1 is essential to control fungal gastrointestinal infection by PPARgamma ligands. We also show that the phagocytosis of yeast and the release of reactive oxygen intermediates in response to Candida albicans challenge are impaired in macrophages from Dectin-1 deficient mice treated with PPARgamma ligands or IL-13. Although the Mannose Receptor is not sufficient to trigger antifungal functions during the alternative activation of macrophages, our data establish the involvement of the Mannose Receptor in the initial recognition of non-opsonized Candida albicans by macrophages. We also demonstrate for the first time that the modulation of Dectin-1 expression by IL-13 involves the PPARgamma signaling pathway. These findings are consistent with a crucial role for PPARgamma in the alternative activation of macrophages by Th2 cytokines. Altogether these data suggest that PPARgamma ligands may be of therapeutic value in esophageal and gastrointestinal candidiasis in patients severely immunocompromised or with metabolic diseases in whom the prevalence of candidiasis is considerable.

The inaccuracy of the usual representations of an actual ship hull, that is of a hull neither thin, nor flat, nor slender, seems to be one of the main causes of the discrepancy between the measured and calculated values of the wave resistance. It is shown in the first part of this paper that a line singularity distribution should be associated with the surface singularity distribution over the hull. In the second part, the order of magnitude of the contribution of the line singularity is evaluated in the particular case of a vertical, elliptical, infinite cylinder. It is considerably high when normal doublet distribution is used. It becomes of the first order at low Froude numbers in the case of a source distribution. The problem still requires extensive research in several directions outlined at the end of the paper.

Abstract BACKGROUND: Optimization of nitrogen (N) and sulfur (S) nutrition of wheat influences the bread‐making quality of grain. This study was conducted to determine whether the application of N and S in winter wheat at anthesis stage during two field trials could influence the absorption and distribution of N and S in grain and flour bread‐making quality RESULTS: The incorporation of 15 N and 34 S tracers in various plant parts (leaves, stems, spikes) was determined by isotopic ratio mass spectrometry coupled with an elemental analyser (EA‐IRMS). The effects of foliar fertilization on percentage of 15 N and 34 S recovery in various plant parts, grain yield, flour protein content, and dough properties were investigated after a combination of treatments: N (urea), S (micronized elemental S) and NS (both urea and micronized elemental S). Nitrogen (70–80%) and S (35–55%) were quickly assimilated during the days following application. Sixty days after application, 42–68% N and 6–12% S were recovered in the grain. When N and S fertilizers were applied simultaneously, N and S recoveries (68% and 12%), N/S ratios (11–14), flour protein content (115 g kg −1 ) and dough strength (310 × 10 −4 J), swelling (21.8 mmH 2 O) and extensibility (96.4 mm) were increased. CONCLUSION: A synergistic effect between the foliar applied N and S fertilizers appears to increase N and S assimilation in grain and may improve bread‐making qualities. Copyright © 2007 Society of Chemical Industry

In bitemark analysis, the forensic odontologist must consider how the biomechanical properties of the skin contribute to distortion of the bitemark. In addition, one must consider how the bitemark can be distorted by postural movement of the victim after the bite has occurred. A fundamental review of the architecture and biomechanical properties of the dermis is described and evaluated through bites made on cadavers. In order to assess distortion, 23 bites from a single characterized dentition were made on un-embalmed cadaver skin. Bite indentations were photographed. Following various body manipulations they were re-photographed in different positions. Hollow volume overlays of the biting dentition were constructed, and metric analysis of the dentition and all bitemarks was completed. The overall intercanine, mesial to distal, and angle of rotation distortion was calculated. Of the 23 bites made, none were measurably identical, and in some cases, dramatic distortion was noted.

Abstract Currently, selection of screw configurations as well as the operating conditions for compounding polymer blends with desired morphology in a co‐rotating twinscrew extruder is an art based on experience. In this paper a quenching section of a twin‐screw extruder is described. The section may replace any segment of the extruder barrel. It allows, on the one hand, a regular operation of the machine, and on the other, a rapid quenching and removal of blend specimens for morphology analysis from any place along the extruder barrel and at any time of the blending. The experimental observation of development during compounding of polymer blends enables verification and improvement of the theoretical model, aimed at predicting and controlling the size and polydispersity of the minor phase. Development of the predictive model for blend morphology will provide a valuable guide to the polymer processing industry. The preliminary data were collected using polystyrene/high density polyethylene (PS/HDPE) blends at low concentration of the dispersed phase, 5 wt% of either PS or HDPE. It was observed that the viscosity ratio, blend composition, screw configuration, temperature, throughput, and screw speed significantly influence the blend morphology.

This paper reports on a functional evaluation of prosthetic feet based on gait analysis. The aim is to analyse prosthetic feet behaviour under loads applied during gait in order to quantify user benefits for each foot. Ten traumatic amputees (six trans-tibial and four trans-femoral) were tested using their own prosthetic foot. An original protocol is presented to calculate the forefoot kinematics together with the overall body kinematics and ground reaction forces during gait. In this work, sagittal motion of the prosthetic ankle and the forefoot, time-distance parameters and ground reaction forces were examined. It is shown that an analysis of not only trans-tibial but also trans-femoral amputees provides an insight in the performance of prosthetic feet. Symmetry and prosthetic propulsive force were proved to be mainly dependant on amputation level. In contrast, the flexion of the prosthetic forefoot and several time-distance parameters are highly influenced by foot design. Correlations show influential of foot and ankle kinematics on other parameters. These results suggest that prosthetic foot efficiency depends simultaneously on foot design and gait style. The evaluation, proposed in this article, associated to clinical examination should help to achieve the best prosthetic foot match to a patient.

We demonstrate tunable radiofrequency emission from a meter-long linear plasma column produced in air at atmospheric pressure. A short-lived plasma column is initially produced by femtosecond filamentation and subsequently converted into a long-lived discharge column by application of an external high voltage field. Radiofrequency excitation is fed to the plasma by induction and detected remotely as electromagnetic radiation by a classical antenna.

BACKGROUND: Empiric treatment of complicated intra-abdominal infections (cIAI) represents a clinical challenge because of the diverse bacteriology and the emergence of bacterial resistance. The efficacy and safety of tigecycline (TGC), a first-in-class, expanded broad-spectrum glycylcycline antibiotic, were compared with imipenem/cilastatin (IMI/CIS) in patients with cIAI. METHODS: In this prospective, double-blind, phase 3, multinational trial, patients were randomly assigned to intravenous (i.v.) TGC (100 mg initial dose, then 50 mg every 12 h) or i.v. IMI/CIS (500/500 mg every 6 h) for 5-14 days. Clinical response was assessed at the test-of-cure (TOC) visit (14-35 days after therapy) for microbiologically evaluable (ME) and microbiologically modified intent-to-treat (m-mITT) populations (co-primary efficacy endpoint populations in which cure/failure response rates were determined). RESULTS: Of 817 mITT patients (i.e., received > or = 1 dose of study drug), 641 (78%) comprised the m-mITT cohort (322 TGC, 319 IMI/CIS) and 523 (64%) were ME (266 TGC, 256 IMI/CIS). Patients were predominantly white (88%) and male (59%) with a mean age of 49 years. The primary diagnoses for the mITT group were complicated appendicitis (41%), cholecystitis (22%), and intra-abdominal abscess (11%). For the ME population, clinical cure rates at TOC were 91.3% (242/265) for TGC versus 89.9% (232/258) for IMI/CIS (95% CI -4.0, 6.8; P<0.001). Corresponding clinical cure rates within the m-mITT population were 86.6% (279/322) for TGC versus 84.6% (270/319) for IMI/CIS (95% CI -3.7, 7.5; P<0.001 for noninferiority TGC versus IMI/CIS). The most commonly reported adverse events for TGC and IMI/CIS were nausea (17.6% TGC versus 13.3% IMI/CIS; P=0.100) and vomiting (12.6% TGC versus 9.2% IMI/CIS; P=0.144). CONCLUSIONS: TGC is efficacious in the treatment of patients with cIAIs and TGC met per the protocol-specified statistical criteria for noninferiority to the comparator, IMI/CIS.

OBJECTIVE: To compare the effects on office blood pressure and home blood pressure of placebo and active drug administration. DESIGN: After a 2-week wash-out period, patients with mild-to-moderate hypertension entered a 2-week single-blind placebo period and then a 4-week double-blind period. Patients were randomly assigned to be administered either 2 mg trandolapril once daily or its placebo in a 2:1 proportion. Office blood pressure was measured by a physician at the end of each period, using a mercury sphygmomanometer (mean of three consecutive measurements). Home blood pressure was measured during the last week of each period according to standard procedure carefully taught to each patient by the physician. Compliance was checked by using electronic pill boxes. RESULTS: Data for 34 of the 44 patients who entered the study were eligible for analysis. Baseline systolic blood pressure/diastolic blood pressure were significantly (P = 0.0001/P = 0.0001) higher for office blood pressure (161/101 mmHg) than they were for home blood pressure (145/93 mmHg). There was no statistically significant difference between the placebo and active-treatment groups at baseline. During the single-blind period, blood pressures measured at the office and at home did not change significantly. Office blood pressure decreased by 2.7 +/- 10 mmHg for systolic blood pressure and by 0.5 +/- 4 mmHg for diastolic blood pressure whereas home blood pressure increased by 0.8 +/- 6 mmHg for systolic blood pressure and by 0.7 +/- 4 mmHg for diastolic blood pressure. During the double-blind period, office blood pressure fell significantly with trandolapril treatment (systolic by 10.2 +/- 12 mmHg, diastolic by 8.3 +/- 6 mmHg; P = 0.0005/0.0001, versus single-blind placebo period) but this decrease was not significantly different (P = 0.45/0.92) from the fall in members of the placebo group (systolic by 6.9 +/- 9 mmHg, diastolic by 8.0 +/-6 mmHg; P = 0.04/0.002, versus single-blind placebo period). Thus, no antihypertensive effect of trandolapril was demonstrated. The fall lin home blood pressure with trandolapril treatment was significant (systolic by 10.7 +/- 8 mmHg, diastolic by 5.8 +/- 5 mmHg; both P = 0.0001, versus single-blind placebo period) and was significantly greater (P = 0.0004/0.004) than the minimal change observed with placebo (systolic fell by 0.2 +/- 5mmHg, diastolic fell by 0.6 +/- 4 mmHg; P = 0.90/0.62, respectively, versus single-blind placebo period). The evening decrease in home blood pressure was similar to the morning decrease in home blood pressure in members of the trandolapril-treated group. The resulting morning:evening decrease in blood pressure ratio was 0.83 for diastolic blood pressure and 0.95 for systolic blood pressure. For the subgroup of responders, mean of individual ratios was 0.77 +/- 0.43 for diastolic blood pressure and 0.70 +/- 0.39 for systolic blood pressure. CONCLUSION: The placebo effect observed with office blood pressure measurements does not occur with home blood pressure measurements. Expected treatment effect can alter a physician's blood pressure readings. The precision of measurements is greater with home blood pressure (there is a lower SD). Use of home blood pressure measurements increases the power of comparative trials, allowing one either to study fewer subjects or to detect a smaller difference in blood pressure.