Ministry of Environment

Cyanobacteria possess many adaptations to develop population maxima or "blooms" in lakes and reservoirs. A potential consequence of freshwater blooms of many cyanobacterial species is the production of potent toxins, including the cyclic hepatotoxins, microcystins (MCs). Approximately 70 MC variants have been isolated. Their toxicity to humans and other animals is well studied, because of public health concerns. This review focuses instead on the production and degradation of MCs in freshwater environments and their effects on aquatic organisms. Genetic research has revealed the existence of MC-related genes, yet the expression of these genes seems to be regulated by complex mechanisms and is influenced by environmental factors. In natural water bodies, the species composition of cyanobacterial communities and the ratio of toxic to nontoxic species and strains are largely responsible for total toxin production. Cyanobacteria play vital roles in aquatic food webs, yet production, accumulation, and toxicity patterns of MCs within aquatic food webs remain obscure.

Tropical forests are global centres of biodiversity and carbon storage. Many tropical countries aspire to protect forest to fulfil biodiversity and climate mitigation policy targets, but the conservation strategies needed to achieve these two functions depend critically on the tropical forest tree diversity-carbon storage relationship. Assessing this relationship is challenging due to the scarcity of inventories where carbon stocks in aboveground biomass and species identifications have been simultaneously and robustly quantified. Here, we compile a unique pan-tropical dataset of 360 plots located in structurally intact old-growth closed-canopy forest, surveyed using standardised methods, allowing a multi-scale evaluation of diversity-carbon relationships in tropical forests. Diversity-carbon relationships among all plots at 1 ha scale across the tropics are absent, and within continents are either weak (Asia) or absent (Amazonia, Africa). A weak positive relationship is detectable within 1 ha plots, indicating that diversity effects in tropical forests may be scale dependent. The absence of clear diversity-carbon relationships at scales relevant to conservation planning means that carbon-centred conservation strategies will inevitably miss many high diversity ecosystems. As tropical forests can have any combination of tree diversity and carbon stocks both require explicit consideration when optimising policies to manage tropical carbon and biodiversity.

In this study, solvent-dependent emitting carbon dots (CDs) were synthesized by simple one-step hydrothermal treatment of <italic>o</italic>-phenylenediamine (<italic>o</italic>PD).

Rivers suffer from multiple stressors acting simultaneously on their biota, but the consequences are poorly quantified at the global scale. We evaluated the biological condition of rivers globally, including the largest proportion of countries from the Global South published to date. We gathered macroinvertebrate- and fish-based assessments from 72,275 and 37,676 sites, respectively, from 64 study regions across six continents and 45 nations. Because assessments were based on differing methods, different systems were consolidated into a 3-class system: Good, Impaired, or Severely Impaired, following common guidelines. The proportion of sites in each class by study area was calculated and each region was assigned a Köppen-Geiger climate type, Human Footprint score (addressing landscape alterations), Human Development Index (HDI) score (addressing social welfare), % rivers with good ambient water quality, % protected freshwater key biodiversity areas; and % of forest area net change rate. We found that 50% of macroinvertebrate sites and 42% of fish sites were in Good condition, whereas 21% and 29% were Severely Impaired, respectively. The poorest biological conditions occurred in Arid and Equatorial climates and the best conditions occurred in Snow climates. Severely Impaired conditions were associated (Pearson correlation coefficient) with higher HDI scores, poorer physico-chemical water quality, and lower proportions of protected freshwater areas. Good biological conditions were associated with good water quality and increased forested areas. It is essential to implement statutory bioassessment programs in Asian, African, and South American countries, and continue them in Oceania, Europe, and North America. There is a need to invest in assessments based on fish, as there is less information globally and fish were strong indicators of degradation. Our study highlights a need to increase the extent and number of protected river catchments, preserve and restore natural forested areas in the catchments, treat wastewater discharges, and improve river connectivity.

Nature(s) have been commodified since the early days of capitalism, but through processes and socio-natural relationships mediated by their times, histories and localities. While the conditions under which nature's commodities are being trademarked today may be new, their potential for commodification is not. Commodifications of nature should not come as a surprise to environmental social scientists and activists. In this article, I argue that commodification of ‘nature's products, places and processes’ produces new sorts of socio-natures. Situated histories of rubber are particularly relevant because, like carbon, ecosystem services and other recently commodified natures, rubber sits comfortably on the line between a fictitious commodity and a commodity produced explicitly for market: the latex alone has almost no use value, and to give it any exchange value, it requires processing. Yet analytically, it is still considered a ‘natural commodity’, different from ‘synthetic rubber’ and other tradable tree latexes in qualities and socio-natural characteristics. However, it is the social relations constituting rubber's production and trade in various rainforest and agro-forestry environments that have given it a positive or negative connotation, rather than its natural properties or the ecological contexts within which it has been produced. By situating rubber in three of its globally important temporal and spatial contexts, I show how it has been subjected to fairy-tale-like stories that masked and naturalized its commodity lives of the moment. Understanding how history is told or remains untold is thus an essential part of the politics of knowledge production, but also of human experience and mobilization for change. It should be part of any political ecology analysis.

The first International Peat Congress (IPC) held in the tropics - in Kuching (Malaysia) - brought together over 1000 international peatland scientists and industrial partners from across the world ("International Peat Congress with over 1000 participants!," 2016). The congress covered all aspects of peatland ecosystems and their management, with a strong focus on the environmental, societal and economic challenges associated with contemporary large-scale agricultural conversion of tropical peat.

Mangrove forests are important carbon sinks and this is especially true for Indonesia where about 24% of the world's mangroves exist. Unfortunately, vast expanses of these mangroves have been deforested, degraded or converted to other uses resulting in significant greenhouse gas emissions. The objective of this study was to quantify the climate change mitigation potential of mangrove conservation and restoration in Indonesia. We calculated the emission factors from the dominant land uses in mangroves, determined mangrove deforestation rates and quantified the total emissions and the potential emission reductions that could be achieved from mangrove conservation and restoration. Based upon our analysis of the carbon stocks and emissions from land use in mangroves we found: (1) Indonesia's mangrove ecosystem carbon stocks are amongst the highest of any tropical forest type; (2) mangrove deforestation results in greenhouse gas emissions that far exceed that of upland tropical deforestation; (3) in the last decade the rates of deforestation in Indonesian mangroves have remained high; and (4) conservation and restoration of mangroves promise to sequester significant quantities of carbon. While mangroves comprise only ≈2.6% of Indonesia's total forest area, their degradation and deforestation accounted for ≈10% of total greenhouse gas emissions arising from the forestry sector. The large source of greenhouse gas emissions from a relatively small proportion of the forest area underscores the value for inclusion of mangroves as a natural climate solution (NCS). Mangrove conservation is far more effective than mangrove restoration in carbon emissions reductions and an efficient pathway to achieve Indonesia's nationally determined contribution (NDC) targets. The potential emission reduction from halting deforestation of primary and secondary mangroves coupled with restoration activities could result in an emission reduction equivalent to 8% of Indonesia's 2030 NDC emission reduction targets from the forestry sector.

BACKGROUND: Mercury (Hg) is toxic to both the reproductive and nervous systems. In addition, glutathione S-transferases (GSTs), which conjugate glutathione to a variety of electrophilic compounds, are involved in the detoxification of Hg. OBJECTIVE: In this study we examined the association between prenatal exposure to Hg and birth weight as well as the influence of GST polymorphisms. METHODS: The total Hg concentration in maternal and cord blood was measured from 417 Korean women and newborns in the Mothers and Children's Environmental Health study from 2006 to 2008. Information on birth weight was collected from the patients' medical records. The genotyping of glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) polymorphisms was carried out using polymerase chain reaction. Regression analysis was performed to determine the association between the blood Hg concentration and birth weight in mothers with GSTM1 and GSTT1 polymorphisms. RESULTS: The geometric mean levels of Hg in the maternal blood during late pregnancy and in cord blood were 3.30 microg/L and 5.53 microg/L, respectively. For mothers with the GSTT1 null genotype, elevated Hg levels in maternal blood during late pregnancy were associated with an increased risk of lower birth weight. For mothers with both GSTM1 and GSTT1 null genotype, both maternal and cord blood Hg levels were associated with lower birth weight. CONCLUSIONS: This study suggests that the interactions of Hg with GSTM1 and GSTT1 polymorphisms play a role in reducing birth weight.

Environmental pollutants have been known to increase the risks of not only respiratory and cardiovascular disease but also metabolic diseases such as obesity and diabetes mellitus (DM). Polycyclic aromatic hydrocarbons (PAHs) and volatile organic compounds (VOCs) such as benzene and toluene are major constituents of environmental pollution. In the present study, we employed the population of the Korean National Environmental Health Survey (KoNEHS) Cycle 3 conducted between 2015 and 2017, and assessed the associations of urinary biomarkers for PAHs and VOCs exposure with obesity and DM. A total of 3787 adult participants were included and the urinary concentrations of four PAH metabolites and two VOC metabolites were measured. For correcting urine dilution, a covariate-adjusted standardization method was used. The highest quartiles of urinary 2-hydroxynaphthalene (2-NAP) [OR (95% confidence interval (CI)) = 1.46 (1.13, 1.87)] and sum of PAH metabolites [OR (95% CI) = 1.45 (1.13, 1.87)] concentrations were associated with a higher risk of obesity [body mass index (BMI)≥25 kg/m2]. BMI was positively associated with urinary 2-NAP [β (95% CI) = 0.25 (0.09, 0.41), p = 0.003] and sum of PAH metabolites [β (95% CI) = 0.29 (0.08, 0.49), p = 0.006] concentrations. The risk of DM was increased with increasing quartile of 2-hydroxyfluorene (2-OHFlu) and trans, trans-muconic acid (t,t-MA) (p for trend<0.05 and < 0.001, respectively). The highest quartile of t,t-MA showed a significantly higher risk of DM [OR (95% CI) = 2.77 (1.74, 4.42)] and obesity [OR (95% CI) = 1.42 (1.06, 1.90)]. Urinary t,t,-MA level was positively associated with BMI [(β (95% CI) = 0.51 (0.31, 0.71), p < 0.001] and non-alcoholic fatty liver disease index [(β (95% CI) = 0.09 (0.06, 0.12), p < 0.001]. In conclusion, the benzene metabolites t,t-MA and PAH metabolite 2-OHFlu were associated with an increased risk of DM. Urinary biomarkers for PAHs and VOCs were positively associated with BMI in the Korean adult population. Further studies to validate these observations in other populations are warranted.

In terms of climate change mitigation, mangroves serve as carbon sinks and the loss of mangrove forests can result in significant release of stored carbon. As the country in the world with the largest cover of mangrove forest, Indonesia has global significance in climate change mitigation. About 22% of mangrove forests in Indonesia are preserved in conservation areas and provide 0.82–1.09 PgC hectare −1 of carbon storage. Greater potential for climate change mitigation can be achieved by increasing mangrove conservation areas that keep mangrove forests from their conversion to other land uses. Our finding confirms the importance of mangrove conservation in storing and sequestering carbon. Furthermore, as mangrove forests are associated with a diversity of ecosystem services with multiple beneficiaries, the carbon benefits will enhance the value of mangrove forest in terms of ecological, social, and economic benefits. However, prioritizing carbon benefits through the implementation of mangrove conservation as part of climate change mitigation may be conflicting with socioeconomic issues. Thus, legal frameworks and the participation of stakeholders, especially local communities, are needed to ensure that there is a net reduction in mangrove loss. This article is categorized under: Climate, Ecology, and Conservation &gt; Conservation Strategies

Geo-Kompsat-2A (Geostationary-Korean Multi-Purpose SATtellite-2A, GK2A), a new generation of Korean geostationary meteorological satellite, carry state-of-the-art optical sensors with significantly higher radiometric, spectral, and spatial resolution than the Communication, Ocean, and Meteorological Satellite (COMS) previously available in the geostationary orbit. The new Advanced Meteorological Imager (AMI) on GK2A has 16 observation channels, and its spatial resolution is 0.5 or 1 km for visible channels and 2 km for near-infrared and infrared channels. These advantages, when combined with shortened revisit times (around 10 min for full disk and 2 min for sectored regions), provide new levels of capacity for the identification and tracking of rapidly changing weather phenomena and for the derivation of quantitative products. These improvements will bring about unprecedented levels of performance in nowcasting services and short-range weather forecasting systems. Imagery from the satellites is distributed and disseminated to users via multiple paths, including internet services and satellite broadcasting services. In post-launch performance validation, infrared channel calibration is accurate to within 0.2 K with no significant diurnal variation using an approach developed under the Global Space-based Inter-Calibration System framework. Visible and near infrared channels showed unexpected seasonal variations of approximately 5 to 10% using the ray matching method and lunar calibration. Image navigation was accurate to within requirements, 42 µrad (1.5 km), and channel-to-channel registration was also validated. This paper describes the features of the GK2A AMI, GK2A ground segment, and data distribution. Early performance results of AMI during the commissioning period are presented to demonstrate the capabilities and applications of the sensor.

Phthalates and bisphenol A (BPA) have been suspected as risk factors for obesity and diabetes mellitus (DM) among humans. However, associations between phthalates and environmental phenols are often inconsistent across different populations. In this study, we recruited the adult population (n = 3782) of the Korean National Environmental Health Survey (KoNEHS) 2015-2017 (Cycle 3) and assessed the associations between urinary biomarkers of phthalate, BPA, and paraben exposure with obesity and DM. A potential collider issue with the use of urinary creatinine (Cr) or specific gravity (SG) exists when adjusting urinary dilution; therefore, a covariate-adjusted standardization (CAS) was employed for adjustment, and the results were compared. In the present population, the direction of the association often varied depending on the choices made to adjust urinary dilution. When using CAS, the direction of association resembled those of previously reported experimental observations. With Cr or SG adjustment, ORs for obesity decreased in the highest quartiles of monocarboxyoctyl phthalate (MCOP) [OR (95% CI) = Cr: 0.71 (0.54, 0.93); SG: 0.68 (0.52, 0.90)], monocarboxy-isononyl phthalate (MCNP) [OR (95% CI) = Cr: 0.67 (0.52, 0.87); SG: 0.68 (0.52, 0.89)], and mono(3-carboxylpropyl) phthalate (MCPP) in the urine [OR (95% CI) = Cr: 0.60 (0.47, 0.76); SG: 0.61 (0.48, 0.77)]; however, with CAS, these negative associations disappeared. Instead, mono-benzyl phthalate (MBzP) [OR (95% CI) = 1.31 (1.03, 1.66)], BPA [OR (95% CI) = 1.62 (1.27, 2.06)], or ethyl paraben (EtP) [OR (95% CI) = 1.51 (1.19, 1.91)] concentrations in the highest quartile showed positive associations with a higher risk of obesity. On the other hand, for DM, an overall decrease in ORs was observed for phthalate metabolites and BPA following SG adjustment and disappeared with CAS adjustment. In addition, the highest quartiles of BPA, methyl paraben (MeP), and ethyl paraben (EtP) showed a significantly higher risk of DM than those in the lowest quartiles following CAS [OR (95% CI) = BPA: 1.65 (1.06, 2.59); MeP: 1.68 (1.08, 2.60); and EtP: 2.74 (1.77, 4.24), respectively]. The present observations outline the importance of using an appropriate adjustment method for urinary dilution in association studies on obesity and DM. In addition, several phthalates, BPA, and parabens were identified as potential chemical risk factors for these outcomes. Further studies are warranted in other populations to confirm these observations.

Freshwater biota are more comprehensive and direct indicators of biological impacts, and more meaningful to the public than water quality or physical habitat surrogates. Freshwater biotic data and the multiple biological indicators developed from them offer a much richer array of data for assessing the impacts of pollution controls than a limited set of physical or chemical measures. In recent decades, assemblage-based assessments by ecologists, environmental scientists, and water quality agencies have been employed globally for determining the condition of, and threats to, freshwater ecosystems. A key step in this advance has been the development of multimetric indices (MMIs) or indices of biotic integrity (IBIs) based on quantitative assessments of algae, macrophyte, macroinvertebrate, fish or riparian bird assemblages. In Europe, where biological assemblages are mandated for assessing freshwater ecosystem health, many indices are multimetric. However, the proliferation of MMIs globally has not always occurred through the application of rigorous study designs and monitoring protocols, nor have they always effectively incorporated functional metrics, stressor assessments, and statistical analyses. Therefore, in this review, we discuss eleven major concerns with the development and application (including logistical limitations) of multimetric indicators based on freshwater biota to encourage more rigorous and widely applicable (transferable) MMI use and implementation. Specifically, our concerns focus on reference conditions; sampling effort, methods, and season; trophic guild definition; metric comprehensiveness, options, screening and scoring; and MMI validation. MMIs could also benefit from increased attention to ecological mechanisms and metric development, to further improve our understanding of anthropogenic impacts as well as rehabilitation effects on freshwater ecosystems globally. Paying closer attention to study designs, ecological mechanisms and metric development should further improve our understanding of anthropogenic impacts and better facilitate rehabilitation of degraded freshwater ecosystems, as well as aiding in the conservation of healthy freshwater ecosystems globally.

ABSTRACT This article makes connections between often‐disparate literatures on property, violence and identity, using the politics of rubber growing in West Kalimantan, Indonesia, as an example. It shows how rubber production gave rise to territorialities associated with and productive of ethnic identities, depending on both the political economies and cultural politics at play in different moments. What it meant to be Chinese and Dayak in colonial and post‐colonial Indonesia, as well as how categories of subjects and citizens were configured in the two respective periods, differentially affected both the formal property rights and the means of access to rubber and land in different parts of West Kalimantan. However, incremental changes in shifting rubber production practices were not the only means of producing territory and ethnicity. The author argues that violence ultimately played a more significant role in erasing prior identity‐based claims and establishing the controls of new actors over trees and land and their claims to legitimate access or ‘rightfulness’. Changing rubber production practices and reconfigurations of racialized territories and identity‐based property rights are all implicated in hiding the violence.

The objective of this research was to access the determination of metabolite profiles and antioxidant properties in the leaves of green perilla (Perilla frutescens), where these are considered functional and nutraceutical substances in Korea. A total of 25 compositions were confirmed as six phenolic acids, two triterpenoids, eight flavonoids, seven fatty acids, and two glucosides using an ultra high performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (UPLC-ESI-Q-TOF-MS/MS) technique from the methanol extract of this species. The individual and total compositions exhibited significant differences, especially rosmarinic acid (10), and linolenic acids (22 and 23) were detected as the predominant metabolites. Interestingly, rosmarinic acid (10) was observed to have considerable differences with various concentrations in three samples (Doryong, 6.38 μg/g; Sinseong, 317.60 μg/g; Bongmyeong, 903.53 μg/g) by UPLC analysis at 330 nm. The scavenging properties against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) radicals also showed potent effects with remarkable differences at a concentration of 100 μg/mL, and their abilities were as follows: Sinseong (DPPH, 86%; ABTS, 90%) > Bongmyeong (71% and 84%, respectively) > Doryong (63% and 73%, respectively). Our results suggest that the antioxidant activities of green perilla leaves are correlated with metabolite contents, especially the five major compositions 10 and 22-25. Moreover, this study may be useful in evaluating the relationship between metabolite composition and antioxidant activity.

BACKGROUND: Exposure to lead (Pb), cadmium (Cd), and mercury (Hg) has been reported to be associated with liver-related diseases. However, studies examining the association between heavy metal exposure and liver injury in a large population are scant and characterized by inconsistent results. This study aimed to evaluate the association between levels of heavy metal exposure and liver injury in the general population. METHODS: Data for 2953 participants aged 19 years or more obtained from the Korean National Environmental Health Survey (KoNEHS) Cycle 3 (2015-2017) were used. The associations between levels of blood or urine heavy metals (Pb, Cd, and Hg) and liver function biomarkers [aspartate aminotransferase (AST), alanine aminotransferase (ALT), and gamma-glutamyl transferase (GGT)] were evaluated using multiple linear regression analysis. RESULTS: Regarding the blood Pb (BPb), AST was higher in those of the 4th quartile, ALT was higher in those of the 2nd and 4th quartiles, and GGT was higher in those of the 3rd and 4th quartiles than in the 1st quartile. For urinary Cd (UCd), AST was higher in those of the 4th quartile; ALT was higher in those of the 2nd, 3rd, and 4th quartiles; and GGT was higher in the 4th quartile than in the 1st quartile. For the blood Hg (BHg), AST was higher in those of the 2nd and 4th quartile, ALT was higher in those of the 2nd, 3rd, and 4th quartiles; and GGT was higher in those of the 3rd and 4th quartiles than in the 1st quartile. There was no significant difference between urinary Hg (UHg) and liver function markers. CONCLUSION: Heavy metal exposure showed an association with liver injury among the general adult population in Korea. Further studies are required to clarify the relationship between heavy metals and liver injury.

This study developed a methodological framework to update the rainfall intensity-duration-frequency (IDF) curves under climate change scenarios. A model output statistics (MOS) method is used to downscale the daily rainfall of general circulation models (GCMs), and an artificial neural network (ANN) is employed for the disaggregation of projected daily rainfall to hourly maximum rainfall, which is then used for the development of IDF curves. Finally, the 1st quartiles, medians, and 3rd quartiles of projected rainfall intensities are estimated for developing IDF curves with uncertainty level. Eight GCM simulations under two radiative concentration pathways (RCP) scenarios, namely, RCP 4.5 and RCP 8.5, are used in the proposed framework for the projection of IDF curves with related uncertainties for peninsular Malaysia. The projection of rainfall revealed an increase in the annual average rainfall throughout the present century. The comparison of the projected IDF curves for the period 2006–2099 with that obtained using GCM hindcasts for the based period (1971–2005) revealed an increase in rainfall intensity for shorter durations and a decrease for longer durations. The uncertainty in rainfall intensity for different return periods for shorter duration is found to be 2 to 6 times more compared to longer duration rainfall, which indicates that a large increase in rainfall intensity for short durations projected by GCMs is highly uncertain for peninsular Malaysia. The IDF curves developed in this study can be used for the planning of climate resilient urban water storm water management infrastructure in Peninsular Malaysia.

Because most efforts to understand the molecular mechanisms underpinning fungal pathogenicity have focused on studying the function and role of individual genes, relatively little is known about how transcriptional machineries globally regulate and coordinate the expression of a large group of genes involved in pathogenesis. Using quantitative real-time PCR, we analyzed the expression patterns of 206 transcription factor (TF) genes in the rice blast fungus Magnaporthe oryzae under 32 conditions, including multiple infection-related developmental stages and various abiotic stresses. The resulting data, which are publicly available via an online platform, provided new insights into how these TFs are regulated and potentially work together to control cellular responses to a diverse array of stimuli. High degrees of differential TF expression were observed under the conditions tested. More than 50% of the 206 TF genes were up-regulated during conidiation and/or in conidia. Mutations in ten conidiation-specific TF genes caused defects in conidiation. Expression patterns in planta were similar to those under oxidative stress conditions. Mutants of in planta inducible genes not only exhibited sensitive to oxidative stress but also failed to infect rice. These experimental validations clearly demonstrated the value of TF expression patterns in predicting the function of individual TF genes. The regulatory network of TF genes revealed by this study provides a solid foundation for elucidating how M. oryzae regulates its pathogenesis, development, and stress responses.

AIM: The focal theme of present investigation includes isolation of prodigiosin producing fish gut bacteria, enhancing its production using tannery solid waste fleshing, and evaluation of its pharmacological effect. METHODS: Optimization of fermentation conditions to yield maximum prodigiosin, and instrumental analysis using FTIR, NMR, ESI-MS, TGA, and DSC. RESULTS: The optimum conditions required for the maximum prodigiosin concentration were achieved at time 30 h, temperature 30°C, pH 8, and 3% substrate concentration. The secondary metabolite was analyzed using ESI-MS, FTIR, and NMR. Therapeutic efficacy was assessed by in vitro anticancer studies. Among the pathogenic bacteria Pseudomonas aeruginosa was most susceptible at the lowest concentration followed by Salmonella typhi. IC₅₀ concentration was cell line specific (HeLa cells: 4.3 µM, HEp2: 5.2 µM, and KB cells: 4.8 µM) and remains nontoxic up to the concentration of 25 µM on normal Vero cells suggesting that cancerous cells are more susceptible to the prodigiosin at lower concentration. CONCLUSION: Maximum prodigiosin production was obtained with tannery fleshing. The potency of the fish gut bacterial secondary metabolite prodigiosin as a therapeutic agent was confirmed through in vitro antimicrobial and anticancer studies.

In this study, we analyzed 27 pharmaceuticals in liquid and solid phase samples collected from the unit processes of four different sewage treatment plants (STPs) to evaluate their distribution and behavior of the pharmaceuticals. The examination of the relative distributions of various categories of pharmaceuticals in the influent showed that non-steroidal anti-inflammatory drugs (NSAIDs) were the most dominant. While the relative distribution of antibiotics in the influent was not high (i.e., 3%–5%), it increased to 14%–30% in the effluent. In the four STPs, the mass load of the target pharmaceuticals was reduced by 88%–95% mainly in the biological treatment process, whereas the ratio of pharmaceuticals in waste sludge to those in the influent (w/w) was only 2%. In all the STPs, the removal efficiencies for the stimulant caffeine, NSAIDs (acetaminophen, naproxen, and acetylsalicylic acid), and the antibiotic cefradine were high; they were removed mainly by biological processes. Certain compounds, such as the NSAID ketoprofen, contrast agent iopromide, lipid regulator gemfibrozil, and antibiotic sulfamethoxazole, showed varying removal efficiencies depending on the contribution of biodegradation and sludge sorption. In addition, a quantitative meta-analysis was performed to compare the pharmaceutical removal efficiencies of the biological treatment processes in the four STPs, which were a membrane bioreactor (MBR) process, sequencing batch reactor (SBR) process, anaerobic–anoxic–oxic (A2O) process, and moving-bed biofilm reactor (MBBR) process. Among the biological processes, the removal efficiency was in the order of MBR &gt; SBR &gt; A2O &gt; MBBR. Among the tertiary treatment processes investigated, powdered activated carbon showed the highest removal efficiency of 18%–63% for gemfibrozil, ibuprofen, ketoprofen, atenolol, cimetidine, and trimethoprim.