Tribhuvan University

BACKGROUND: We have previously estimated that respiratory syncytial virus (RSV) was associated with 22% of all episodes of (severe) acute lower respiratory infection (ALRI) resulting in 55 000 to 199 000 deaths in children younger than 5 years in 2005. In the past 5 years, major research activity on RSV has yielded substantial new data from developing countries. With a considerably expanded dataset from a large international collaboration, we aimed to estimate the global incidence, hospital admission rate, and mortality from RSV-ALRI episodes in young children in 2015. METHODS: We estimated the incidence and hospital admission rate of RSV-associated ALRI (RSV-ALRI) in children younger than 5 years stratified by age and World Bank income regions from a systematic review of studies published between Jan 1, 1995, and Dec 31, 2016, and unpublished data from 76 high quality population-based studies. We estimated the RSV-ALRI incidence for 132 developing countries using a risk factor-based model and 2015 population estimates. We estimated the in-hospital RSV-ALRI mortality by combining in-hospital case fatality ratios with hospital admission estimates from hospital-based (published and unpublished) studies. We also estimated overall RSV-ALRI mortality by identifying studies reporting monthly data for ALRI mortality in the community and RSV activity. FINDINGS: We estimated that globally in 2015, 33·1 million (uncertainty range [UR] 21·6-50·3) episodes of RSV-ALRI, resulted in about 3·2 million (2·7-3·8) hospital admissions, and 59 600 (48 000-74 500) in-hospital deaths in children younger than 5 years. In children younger than 6 months, 1·4 million (UR 1·2-1·7) hospital admissions, and 27 300 (UR 20 700-36 200) in-hospital deaths were due to RSV-ALRI. We also estimated that the overall RSV-ALRI mortality could be as high as 118 200 (UR 94 600-149 400). Incidence and mortality varied substantially from year to year in any given population. INTERPRETATION: Globally, RSV is a common cause of childhood ALRI and a major cause of hospital admissions in young children, resulting in a substantial burden on health-care services. About 45% of hospital admissions and in-hospital deaths due to RSV-ALRI occur in children younger than 6 months. An effective maternal RSV vaccine or monoclonal antibody could have a substantial effect on disease burden in this age group. FUNDING: The Bill & Melinda Gates Foundation.

IMPORTANCE: The Global Burden of Diseases, Injuries, and Risk Factors Study 2019 (GBD 2019) provided systematic estimates of incidence, morbidity, and mortality to inform local and international efforts toward reducing cancer burden. OBJECTIVE: To estimate cancer burden and trends globally for 204 countries and territories and by Sociodemographic Index (SDI) quintiles from 2010 to 2019. EVIDENCE REVIEW: The GBD 2019 estimation methods were used to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life years (DALYs) in 2019 and over the past decade. Estimates are also provided by quintiles of the SDI, a composite measure of educational attainment, income per capita, and total fertility rate for those younger than 25 years. Estimates include 95% uncertainty intervals (UIs). FINDINGS: In 2019, there were an estimated 23.6 million (95% UI, 22.2-24.9 million) new cancer cases (17.2 million when excluding nonmelanoma skin cancer) and 10.0 million (95% UI, 9.36-10.6 million) cancer deaths globally, with an estimated 250 million (235-264 million) DALYs due to cancer. Since 2010, these represented a 26.3% (95% UI, 20.3%-32.3%) increase in new cases, a 20.9% (95% UI, 14.2%-27.6%) increase in deaths, and a 16.0% (95% UI, 9.3%-22.8%) increase in DALYs. Among 22 groups of diseases and injuries in the GBD 2019 study, cancer was second only to cardiovascular diseases for the number of deaths, years of life lost, and DALYs globally in 2019. Cancer burden differed across SDI quintiles. The proportion of years lived with disability that contributed to DALYs increased with SDI, ranging from 1.4% (1.1%-1.8%) in the low SDI quintile to 5.7% (4.2%-7.1%) in the high SDI quintile. While the high SDI quintile had the highest number of new cases in 2019, the middle SDI quintile had the highest number of cancer deaths and DALYs. From 2010 to 2019, the largest percentage increase in the numbers of cases and deaths occurred in the low and low-middle SDI quintiles. CONCLUSIONS AND RELEVANCE: The results of this systematic analysis suggest that the global burden of cancer is substantial and growing, with burden differing by SDI. These results provide comprehensive and comparable estimates that can potentially inform efforts toward equitable cancer control around the world.

Most of recent research on layered chalcogenides is understandably focused on single atomic layers. However, it is unclear if single-layer units are the most ideal structures for enhanced gas-solid interactions. To probe this issue further, we have prepared large-area MoS2 sheets ranging from single to multiple layers on 300 nm SiO2/Si substrates using the micromechanical exfoliation method. The thickness and layering of the sheets were identified by optical microscope, invoking recently reported specific optical color contrast, and further confirmed by AFM and Raman spectroscopy. The MoS2 transistors with different thicknesses were assessed for gas-sensing performances with exposure to NO2, NH3, and humidity in different conditions such as gate bias and light irradiation. The results show that, compared to the single-layer counterpart, transistors of few MoS2 layers exhibit excellent sensitivity, recovery, and ability to be manipulated by gate bias and green light. Further, our ab initio DFT calculations on single-layer and bilayer MoS2 show that the charge transfer is the reason for the decrease in resistance in the presence of applied field.

Eight selected wild vegetables from Nepal (Alternanthera sessilis, Basella alba, Cassia tora, Digera muricata, Ipomoea aquatica, Leucas cephalotes, Portulaca oleracea and Solanum nigrum) were investigated for their antioxidative potential using 2,2-dyphenyl-1-picrylhydrazyl (DPPH) scavenging, hydrogen peroxide (H2O2), ferric reducing antioxidant power (FRAP), and ferric thiocyanate (FTC) methods. Among the selected plant extracts C. tora displayed the highest DPPH radical scavenging activity with an IC50 value 9.898 μg/mL, whereas A. sessilis had the maximum H2O2 scavenging activity with an IC50 value 16.25 μg/mL—very close to that of ascorbic acid (16.26 μg/mL). C. tora showed the highest absorbance in the FRAP assay and the lowest lipid peroxidation in the FTC assay. A methanol extract of A. sessilis resulted in the greatest phenolic content (292.65 ± 0.42 mg gallic acid equivalent (GAE)/g) measured by the Folin–Ciocalteu reagent method, while the smallest content was recorded for B. alba (72.66 ± 0.46 GAE/g). The greatest flavonoid content was observed with extracts of P. oleracea (39.38 ± 0.57 mg quercetin equivalents (QE)/g) as measured by an aluminium chloride colorimetric method, while the least was recorded for I. aquatica (6.61 ± 0.42 QE/g). There was a strong correlation between antioxidant activity with total phenolic (DPPH, R2 = 0.75; H2O2, R2 = 0.71) and total flavonoid content (DPPH, R2 = 0.84; H2O2, R2 = 0.66). This study demonstrates that these wild edible leafy plants could be a potential source of natural antioxidants.

Heavy metal (HM) poisoning of agricultural soils poses a serious risk to plant life, human health, and global food supply. When HM levels in agricultural soils get to dangerous levels, it harms crop health and yield. Chromium (Cr), arsenic (As), nickel (Ni), cadmium (Cd), lead (Pb), mercury (Hg), zinc (Zn), and copper (Cu) are the main heavy metals. The environment contains these metals in varying degrees, such as in soil, food, water, and even the air. These substances damage plants and alter soil characteristics, which lowers crop yield. Crop types, growing circumstances, elemental toxicity, developmental stage, soil physical and chemical properties, and the presence and bioavailability of heavy metals (HMs) in the soil solution are some of the factors affecting the amount of HM toxicity in crops. By interfering with the normal structure and function of cellular components, HMs can impede various metabolic and developmental processes. Humans are exposed to numerous serious diseases by consuming these affected plant products. Exposure to certain metals can harm the kidneys, brain, intestines, lungs, liver, and other organs of the human body. This review assesses (1) contamination of heavy metals in soils through different sources, like anthropogenic and natural; (2) the effect on microorganisms and the chemical and physical properties of soil; (3) the effect on plants as well as crop production; and (4) entering the food chain and associated hazards to human health. Lastly, we identified certain research gaps and suggested further study. If people want to feel safe in their surroundings, there needs to be stringent regulation of the release of heavy metals into the environment.

Regional mapping, stratigraphic study, and 40 Ar/ 39 Ar geochronology provide the basis for an incremental restoration of the Himalayan fold‐thrust belt in western Nepal. Tectonostratigraphic zonation developed in other regions of the Himalaya is applicable, with minor modifications, in western Nepal. From south to north the major structural features are (1) the Main Frontal thrust system, comprising the Main Frontal thrust and two to three thrust sheets of Neogene foreland basin deposits; (2) the Main Boundary thrust sheet, which consists of Proterozoic to early Miocene, Lesser Himalayan metasedimentary rocks; (3) the Ramgarh thrust sheet, composed of Paleoproterozoic low‐grade metasedimentary rocks; (4) the Dadeldhura thrust sheet, which consists of medium‐grade metamorphic rocks, Cambrian‐Ordovician granite and granitic mylonite, and early Paleozoic Tethyan rocks; (5) the Lesser Himalayan duplex, which is a large composite antiformal stack and hinterland dipping duplex; and (6) the Main Central thrust zone, a broad ductile shear zone. The major structures formed in a general southward progression beginning with the Main Central thrust in late early Miocene time. Eocene‐Oligocene thrusting in the Tibetan Himalaya, north of the study area, is inferred from the detrital unroofing record. On the basis of 40 Ar/ 39 Ar cooling ages and provenance data from synorogenic sediments, emplacement of the Dadeldhura thrust sheet took place in early Miocene time. The Ramgarh thrust sheet was emplaced between ∼15 and ∼10 Ma. The Lesser Himalayan duplex began to grow by ∼10 Ma, simultaneously folding the north limb of the Dadeldhura synform. The Main Boundary thrust became active in latest Miocene‐Pliocene time; transport of its hanging wall rocks over an ∼8‐km‐high footwall ramp folded the south limb of the Dadeldhura synform. Thrusts in the Subhimalayan zone became active in Pliocene time. The minimum total shortening in this portion of the Himalayan fold‐thrust belt since early Miocene time (excluding the Tibetan zone) is ∼418–493 km, the variation depending on the actual amounts of shortening accommodated by the Main Central and Dadeldhura thrusts. The rate of shortening ranges between 19 and 22 mm/yr for this period of time. When previous estimates of shortening in the Tibetan Himalaya are included, the minimum total amount of shortening in the foldthrust belt amounts to 628–667 km. This estimate neglects shortening accommodated by small‐scale structures and internal strain and is therefore likely to fall significantly below the actual amount of total shortening.

The Ebola virus disease outbreak in West Africa was unprecedented in both its scale and impact. Out of this human calamity has come renewed attention to global health security--its definition, meaning, and the practical implications for programmes and policy. For example, how does a government begin to strengthen its core public health capacities, as demanded by the International Health Regulations? What counts as a global health security concern? In the context of the governance of global health, including WHO reform, it will be important to distil lessons learned from the Ebola outbreak. The Lancet invited a group of respected global health practitioners to reflect on these lessons, to explore the idea of global health security, and to offer suggestions for next steps. Their contributions describe some of the major threats to individual and collective human health, as well as the values and recommendations that should be considered to counteract such threats in the future. Many different perspectives are proposed. Their common goal is a more sustainable and resilient society for human health and wellbeing.

Coseismic landslides pose immediate and prolonged hazards to mountainous communities, and provide a rare opportunity to study the effect of large earthquakes on erosion and sediment budgets. By mapping landslides using high-resolution satellite imagery, we find that the 25 April 2015 Mw7.8 Gorkha earthquake and aftershock sequence produced at least 25,000 landslides throughout the steep Himalayan Mountains in central Nepal. Despite early reports claiming lower than expected landslide activity, our results show that the total number, area, and volume of landslides associated with the Gorkha event are consistent with expectations, when compared to prior landslide-triggering earthquakes around the world. The extent of landsliding mimics the extent of fault rupture along the east-west trace of the Main Himalayan Thrust and increases eastward following the progression of rupture. In this event, maximum modeled Peak Ground Acceleration (PGA) and the steepest topographic slopes of the High Himalaya are not spatially coincident, so it is not surprising that landslide density correlates neither with PGA nor steepest slopes on their own. Instead, we find that the highest landslide density is located at the confluence of steep slopes, high mean annual precipitation, and proximity to the deepest part of the fault rupture from which 0.5–2 Hz seismic energy originated. We suggest that landslide density was determined by a combination of earthquake source characteristics, slope distributions, and the influence of precipitation on rock strength via weathering and changes in vegetation cover. Determining the relative contribution of each factor will require further modeling and better constrained seismic parameters, both of which are likely to be developed in the coming few years as post-event studies evolve. Landslide mobility, in terms of the ratio of runout distance to fall height, is comparable to small volume landslides in other settings, and landslide volume-runout scaling is consistent with compilations of data on larger slope failures. In general, the size ratios of landslide source area to full landslide area are smaller than global averages, and hillslope length seems to largely control runout distance, which we propose reflects a topographic control on landslide mobility in this setting. We find that landslide size dictates runout distance and that more than half of the landslide debris was deposited in direct connection with stream channels. Connectivity, which is defined as the spatial proximity of landslides to fluvial channels, is greatest for larger landslides in the high-relief part of the High Himalaya. Although these failures are less abundant than those at lower elevations, they may have a disproportionate impact on sediment dynamics and cascading hazards, such as landslide reactivation by monsoon rainfall and landslide dams that lead to outburst floods. The overall high fluvial connectivity of coseismic landsliding in the Gorkha event suggests coupling between the earthquake cycle and sediment/geochemical budgets of fluvial systems in the Himalaya.

The Gorkha earthquake (magnitude 7.8) on 25 April 2015 and later aftershocks struck South Asia, killing ~9000 people and damaging a large region. Supported by a large campaign of responsive satellite data acquisitions over the earthquake disaster zone, our team undertook a satellite image survey of the earthquakes' induced geohazards in Nepal and China and an assessment of the geomorphic, tectonic, and lithologic controls on quake-induced landslides. Timely analysis and communication aided response and recovery and informed decision-makers. We mapped 4312 coseismic and postseismic landslides. We also surveyed 491 glacier lakes for earthquake damage but found only nine landslide-impacted lakes and no visible satellite evidence of outbursts. Landslide densities correlate with slope, peak ground acceleration, surface downdrop, and specific metamorphic lithologies and large plutonic intrusions.

Reproducible climate reconstructions of the Common Era (1 CE to present) are key to placing industrial-era warming into the context of natural climatic variability. Here we present a community-sourced database of temperature-sensitive proxy records from the PAGES2k initiative. The database gathers 692 records from 648 locations, including all continental regions and major ocean basins. The records are from trees, ice, sediment, corals, speleothems, documentary evidence, and other archives. They range in length from 50 to 2000 years, with a median of 547 years, while temporal resolution ranges from biweekly to centennial. Nearly half of the proxy time series are significantly correlated with HadCRUT4.2 surface temperature over the period 1850-2014. Global temperature composites show a remarkable degree of coherence between high- and low-resolution archives, with broadly similar patterns across archive types, terrestrial versus marine locations, and screening criteria. The database is suited to investigations of global and regional temperature variability over the Common Era, and is shared in the Linked Paleo Data (LiPD) format, including serializations in Matlab, R and Python.

The emergence and spread of antibiotic resistance, as well as the evolution of new strains of disease causing agents, are of great concern to the global health community. Effective treatment of a disease entails the development of new pharmaceuticals or some potential source of novel drugs. Commonly used medicinal plants of our community could be an excellent source of drugs to fight off this problem. This study is focused on exploring the antimicrobial properties of the plants that are commonly being used as traditional medicines. The antimicrobial potential of four different plant extracts was screened against twelve pathogenic microorganisms and two reference bacterial strains. Methanolic extracts of Oxalis corniculata , Artemisia vulgaris , Cinnamomum tamala , and Ageratina adenophora were subjected to a test of their antimicrobial properties by agar well diffusion method. The result indicated that most of the extracts exhibited antimicrobial properties. The highest potential was observed in the extract of O. corniculata against Escherichia coli, Salmonella Typhi, MDR Salmonella Typhi, Klebsiella pneumoniae, and Citrobacter koseri with zone of inhibition (ZOI) of 17 mm, 13 mm, 16 mm, 11 mm, and 12 mm, respectively. Oxalis corniculata also showed the highest MIC against test organisms. The methanolic extract of Artemisia vulgaris , Cinnamomum tamala, and Ageratina adenophora showed efficacy against Staphylococcus aureus. Ageratina adenophora also showed antifungal activity against Rhizopus spp. The experiment confirmed the efficacy of some selected plant extracts as natural antimicrobials and suggested the possibility of employing them in drugs for the treatment of infectious diseases caused by the test organisms.

BACKGROUND: Plant species have long been used as principal ingredients of traditional medicine in far-west Nepal. The medicinal plants with ethnomedicinal values are currently being screened for their therapeutic potential but their data and information are inadequately compared and analyzed with the Ayurveda and the phytochemical findings. METHODS: The present study evaluated ethnomedicinal plants and their uses following literature review, comparison, field observations, and analysis. Comparison was made against earlier standard literature of medicinal plants and ethnomedicine of the same area, the common uses of the Ayurveda and the latest common phytochemical findings. The field study for primary data collection was carried out from 2006-2008. RESULTS: The herbal medicine in far-west Nepal is the basis of treatment of most illness through traditional knowledge. The medicine is made available via ancient, natural health care practices such as tribal lore, home herbal remedy, and the Baidhya, Ayurveda and Amchi systems. The traditional herbal medicine has not only survived but also thrived in the trans-cultural environment with its intermixture of ethnic traditions and beliefs. The present assessment showed that traditional herbal medicine has flourished in rural areas where modern medicine is parsimoniously accessed because of the high cost and long travel time to health center. Of the 48 Nepalese medicinal plants assessed in the present communication, about half of the species showed affinity with the common uses of the Ayurveda, earlier studies and the latest phytochemical findings. The folk uses of Acacia catechu for cold and cough, Aconitum spicatum as an analgesic, Aesculus indica for joint pain, Andrographis paniculata for fever, Anisomeles indica for urinary affections, Azadirachta indica for fever, Euphorbia hirta for asthma, Taxus wallichiana for tumor control, and Tinospora sinensis for diabetes are consistent with the latest pharmacological findings, common Ayurvedic and earlier uses. CONCLUSIONS: Although traditional herbal medicine is only a primary means of health care in far-west Nepal, the medicine has been pursued indigenously with complementing pharmacology and the Ayurveda. Therefore, further pharmacological evaluation of traditional herbal medicine deserves more attention.

The pandemic COVID-19 has forcefully shifted the mode of teaching and learning from only face to face to online in the higher education of Nepal, which is new experiences and practices for many of the teachers and students. In this context, this study investigated teachers’ and learners’ perspectives on online education in relation to its benefits, challenges and strategies during and after COVID-19 in higher education of Nepal. To achieve this objective, online survey research design was employed. Survey questionnaire were used in the study to determine the perspectives of 280 teachers and students from five universities of Nepal. The results showed that the participants experienced online education beneficial primarily for promoting online research, connecting the practitioners to the global community and getting huge and authentic resource of knowledge though they have found time-management skills, more freedom to the teachers and learners, and reliable internet at workplace as the extreme challenges. The research also revealed time management skills, technological prepared and computer literate are the basic qualities for the practitioners who want to have online education. The participants suggested that ICT policy should be clear and courses should be developed accordingly. Only online mode of teaching and learning in the context of Nepal cannot be effective so the participants preferred blended learning. The findings of the research indicated that online education can be an alternative means of traditional education. Thus, if blended approach is implemented, the education process would be more effective and successful in the contexts like Nepal.

Himalayan rivers are frequently hit by catastrophic floods that are caused by the failure of glacial lake and landslide dams; however, the dynamics and long-term impacts of such floods remain poorly understood. We present a comprehensive set of observations that capture the July 2016 glacial lake outburst flood (GLOF) in the Bhotekoshi/Sunkoshi River of Nepal. Seismic records of the flood provide new insights into GLOF mechanics and their ability to mobilize large boulders that otherwise prevent channel erosion. Because of this boulder mobilization, GLOF impacts far exceed those of the annual summer monsoon, and GLOFs may dominate fluvial erosion and channel-hillslope coupling many tens of kilometers downstream of glaciated areas. Long-term valley evolution in these regions may therefore be driven by GLOF frequency and magnitude, rather than by precipitation.

Research Article| January 01, 1998 Neogene foreland basin deposits, erosional unroofing, and the kinematic history of the Himalayan fold-thrust belt, western Nepal P. G. DeCelles; P. G. DeCelles 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 Search for other works by this author on: GSW Google Scholar G. E. Gehrels; G. E. Gehrels 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 Search for other works by this author on: GSW Google Scholar J. Quade; J. Quade 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 Search for other works by this author on: GSW Google Scholar T. P. Ojha; T. P. Ojha 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 Search for other works by this author on: GSW Google Scholar P. A. Kapp; P. A. Kapp 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 Search for other works by this author on: GSW Google Scholar B. N. Upreti B. N. Upreti 2Department of Geology, Tribhuvan University, Tri-Chandra Campus, Ghantaghar, Kathmandu, Nepal Search for other works by this author on: GSW Google Scholar Author and Article Information P. G. DeCelles 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 G. E. Gehrels 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 J. Quade 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 T. P. Ojha 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 P. A. Kapp 1Department of Geosciences, University of Arizona, Tucson, Arizona 85721 B. N. Upreti 2Department of Geology, Tribhuvan University, Tri-Chandra Campus, Ghantaghar, Kathmandu, Nepal Publisher: Geological Society of America First Online: 01 Jun 2017 Online ISSN: 1943-2674 Print ISSN: 0016-7606 Geological Society of America GSA Bulletin (1998) 110 (1): 2–21. https://doi.org/10.1130/0016-7606(1998)110<0002:NFBDEU>2.3.CO;2 Article history First Online: 01 Jun 2017 Cite View This Citation Add to Citation Manager Share Icon Share Facebook Twitter LinkedIn Email Permissions Search Site Citation P. G. DeCelles, G. E. Gehrels, J. Quade, T. P. Ojha, P. A. Kapp, B. N. Upreti; Neogene foreland basin deposits, erosional unroofing, and the kinematic history of the Himalayan fold-thrust belt, western Nepal. GSA Bulletin 1998;; 110 (1): 2–21. doi: https://doi.org/10.1130/0016-7606(1998)110<0002:NFBDEU>2.3.CO;2 Download citation file: Ris (Zotero) Refmanager EasyBib Bookends Mendeley Papers EndNote RefWorks BibTex toolbar search Search Dropdown Menu toolbar search search input Search input auto suggest filter your search All ContentBy SocietyGSA Bulletin Search Advanced Search Abstract Sedimentological and provenance data from the lower Miocene–Pliocene Dumri Formation and Siwalik Group in western Nepal provide new information about the timing of thrust faulting and the links between erosional unroofing of the Himalaya and the Cenozoic 87Sr/86Sr record of the ocean. In western Nepal, the Dumri Formation is an ∼750–1300-m-thick fluvial sandstone and overbank mudstone unit. The Siwalik Group is >4200 m thick and consists of a lower member (>850 m) of 2–12-m-thick fluvial channel sandstones and oxidized calcareous paleosols, a middle member (>2400 m) of very thick (>20 m) channel sandstones and mainly organic-rich Histosols, and an upper member (>1000 m) composed of gravelly braided river deposits. Paleocurrent data indicate that middle Miocene–Pliocene rivers in western Nepal flowed southward, transverse to the thrust belt, throughout deposition of the Siwalik Group. No evidence was found for an axial fluvial trunk system (i.e., the paleo-Ganges River) in Siwalik Group sandstones. A major increase in fluvial channel size is recorded by the transition from lower to middle Siwalik members at ∼10.8 Ma, probably in response to an increase in seasonal discharge.Modal petrographic data from sandstones in the Dumri Formation and the Siwalik Group manifest an upsection enrichment in potassium feldspar, carbonate lithic fragments, and high-grade metamorphic minerals. Modal petrographic analyses of modern river sands provide some control on potential source terranes for the Miocene–Pliocene sandstones. The Dumri Formation was most likely derived from erosion of sedimentary and low-grade metasedimentary rocks in the Tibetan (Tethyan) Himalayan zone during early Miocene emplacement of the Main Central thrust. The presence in Dumri sandstones of plagioclase grains suggests exposure of crystalline rocks of the Greater Himalayan zone, perhaps in response to tectonic unroofing by extensional detachment faults of the South Tibetan detachment system. During deposition of the lower Siwalik Group (∼15–11 Ma), emplacement of the Dadeldhura thrust sheet (one of the synformal crystalline thrust sheets of the southern Himalaya) on top of the Dumri Formation supplied abundant metasedimentary lithic fragments to the foreland basin. A steady supply of plagioclase grains and high-grade minerals was maintained by deeper erosion into the Main Central thrust sheet. From ∼11 Ma to the present, K-feldspar sand increased steadily, suggesting that granitic source rocks became widely exposed during deposition of the upper part of the lower Siwalik Group. This provenance change was caused by erosion of passively uplifted granites and granitic orthogneisses in the Dadeldhura thrust sheet above a large duplex in the Lesser Himalayan rocks. Since the onset of deposition of the conglomeratic upper Siwalik Group (∼4–5 Ma), fault slip in this duplex has been fed updip and southward into the Main Boundary and Main Frontal thrust systems.We obtained 113 U-Pb ages on detrital zircons from modern rivers and Siwalik Group sandstones that cluster at 460–530 Ma, ∼850–1200 Ma, ∼1.8–2.0 Ga, and ∼2.5 Ga. An abundance of Cambrian–Ordovician grains in the Siwalik Group suggests sources of Siwalik detritus in the granites of the Dadeldhura thrust sheet and possibly the Greater Himalayan orthogneisses. The older ages are consistent with sources in the Greater and Lesser Himalayan zones. An overall upsection increase in zircons older than 1.7 Ga suggests increasing aerial exposure of Lesser Himalayan rocks. None of the detrital zircons (even in the modern river samples) yielded a Cenozoic age that might suggest derivation from the Cenozoic Greater Himalayan leucogranites, but this may be attributable to the inheritance problems that characterize the U-Pb geochronology of the leucogranites.When compared with recent studies of the 87Sr/86Sr composition of paleosol carbonate nodules and detrital carbonate in paleosols from the Siwalik Group, the provenance data suggest that erosion and weathering of metamorphosed carbonate rocks in the Lesser Himalayan zone and Cambrian–Ordovician granitic rocks of the crystalline thrust sheets in central and eastern Nepal may have played a significant role in elevating the 87Sr/86Sr ratio of middle Miocene synorogenic sediments in the Indo-Gangetic foreland basin and the Bengal fan, as well as global seawater. 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BACKGROUND: Modern therapeutic medicine is historically based on indigenous therapies and ethnopharmacological uses, which have become recognized tools in the search for new sources of pharmaceuticals. Globalization of herbal medicine along with uncontrolled exploitative practices and lack of concerted conservation efforts, have pushed many of Nepal's medicinal plants to the verge of extinction. Sustainable utilization and management of medicinal plants, based on traditional knowledge, is therefore necessary. METHODS: After establishing verbal informed consent with participating communities, five field surveys, roughly 20 days in duration, were carried out. In all, 176 schedules were surveyed, and 52 participants were consulted through focus group discussions and informal meetings. Altogether, 24 key informants were surveyed to verify and validate the data. A total of 252 individuals, representing non-timber forest product (NTFP) collectors, cultivators, traders, traditional healers (Baidhya), community members, etc. participated in study. Medicinal plants were free-listed and their vernacular names and folk uses were collected, recorded, and applied to assess agreement among respondents about traditional medicines, markets and management. RESULTS: Within the study area, medicinal herbs were the main ingredients of traditional therapies, and they were considered a main lifeline and frequently were the first choice. About 55% plants were ethnomedicinal, and about 37% of ethnomedicinal plants possessed the highest informant consensus value (0.86-1.00). Use of Cordyceps sinensis as an aphrodisiac, Berberis asiatica for eye problems, Bergenia ciliata for disintegration of calculi, Sapindus mukorossi for dandruff, and Zanthoxylum armatum for toothache were the most frequently mentioned. These species possess potential for pharmacology. CONCLUSION: Medicinal plants are inseparable from local livelihoods because they have long been collected, consumed, and managed through local customs and knowledge. Management of traditional therapies is urged, because the therapies are empirically and knowledge based, often culturally inherited and important to pharmacology and local livelihoods. However, traditional therapies are currently being eroded due to changing lifestyles, perceptions, social transformations, and acculturation.

Lack of reliable and valid measures of therapist competence is a barrier to dissemination and implementation of psychological treatments in global mental health. We developed the ENhancing Assessment of Common Therapeutic factors (ENACT) rating scale for training and supervision across settings varied by culture and access to mental health resources. We employed a four-step process in Nepal: (1) Item generation: We extracted 1081 items (grouped into 104 domains) from 56 existing tools; role-plays with Nepali therapists generated 11 additional domains. (2) Item relevance: From the 115 domains, Nepali therapists selected 49 domains of therapeutic importance and high comprehensibility. (3) Item utility: We piloted the ENACT scale through rating role-play videotapes, patient session transcripts, and live observations of primary care workers in trainings for psychological treatments and the Mental Health Gap Action Programme (mhGAP). (4) Inter-rater reliability was acceptable for experts (intraclass correlation coefficient, ICC(2,7) = 0.88 (95% confidence interval (CI) 0.81-0.93), N = 7) and non-specialists (ICC(1,3) = 0.67 (95% CI 0.60-0.73), N = 34). In sum, the ENACT scale is an 18-item assessment for common factors in psychological treatments, including task-sharing initiatives with non-specialists across cultural settings. Further research is needed to evaluate applications for therapy quality and association with patient outcomes.

BACKGROUND: Canarium patentinervium leaves are used by the local indigenous people of Malaysia for wound healing. The current study is undertaken to screen the comprehensive antibacterial activity of the leaves and barks extracts, fractions and isolated compounds from this plant. Bioassay guided fractionation was also undertaken to deeply evaluate the antibacterial activity of the water fraction of the leaves extract. This is to provide preliminary scientific evidence to the ethnopharmacology usage of this plant by investigating antibacterial properties of the plant and its isolated constituents. METHODS: Bio-assay guided fractionation and subsequent isolation of compounds using open column chromatography. The antibacterial activity against gram positive and gram negative ATCC strain and resistant clinical strains were evaluated using microtiter broth dilution method to determine minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC) and time-kill assay. The chemical structure of the isolated compounds from the water fraction of the ethanol extract of leaves was elucidated using Nuclear Magnetic Resonance (NMR). RESULTS: The ethanol extract of the leaves and barks showed antimicrobial activity against all four ATCC and eight clinical isolates. The ethanol extract of the leaves and the corresponding water fraction had good activity against MRSA S. aureus. (MIC: 250 μg/ml) and had bactericidal effect on eight of the clinical strains (MSSA,MRSA, oxacillin-resistant CONS, oxacillin-sensitive CONS, Enterococcus faecalis, Klebsiela species, Kleb pneumoniae ESBL and Candida parapsilosis). Further phytochemical investigation of the water fraction of the crude ethanol extract of leaves afforded compound 7 (hyperin) and compound 8 (cynaroside) that had bactericidal activity against tested bacterial species (MIC 50 μg/ml and 100 μg/ml). The two compounds were isolated from this genus for the first time. CONCLUSIONS: These results may provide a rational support for the traditional use of Canarium patentinervium Miq. in infections and wound healing, since the antimicrobial compounds isolated were also present in the leaves extract.

Collecting research data through traditional approaches (face-to-face, postal or telephone survey) can be costly and time consuming. The emerging data collection approach based on internet/e-based technologies (e.g. online platforms and email), is a relatively cost effective survey alternative. These novel data collection strategies can collect large amounts of data from participants in a short time frame. Similarly, they also seem to be feasible and effective in collecting data on sensitive issues or with samples they are generally hard to reach, for example, men who have sex with men (MSM) or migrants. As a significant proportion of the population currently in the world are digitally connected, the shift from postal (paper-pencil) or telephone towards online survey use in research is in the interests of researchers in academia as well as in the commercial world. However, compared to designing and executing paper version of the questionnaire, there is limited literature to help a starting researcher with the design and a use of online questionnaires. This short paper highlights issues around: a) methodological aspect of online questionnaire survey; b) online survey planning and management; and c) ethical concerns that may arise while using this option. We believe that this paper will be useful for researchers who want to gain knowledge or apply this approach in their research.

Over the past couple of decades, nanomaterials have advanced the research in materials; biomedical, biological, and chemical sciences; etc., owing to their peculiar properties at the nanoregime compared to their bulk composition. Applications of nanoparticles in the fields like medicine and agriculture have been boosted due to the development of different methodologies developed to synthesize specific shapes and sizes. Silver nanoparticles have tunable physical and chemical properties, so it has been studied widely to improve its applicability. The antimicrobial properties of Ag NPs are finding their application in enhancing the activity of drugs (like Amphotericin B, Nystatin, Fluconazole) and composite scaffolds for controlled release of drugs and targeted delivery of drugs due to their low toxicity and biocompatibility. Similarly, their surface plasmon resonance property makes Ag NPs a top-notch material for developing (bio)sensors, for instance, in surface-enhanced Raman spectroscopy, for detecting biomarkers, diseases, pollutants, and higher catalytic activity in photochemical reactions. Besides these, highly conducting Ag NPs are used in wearable and flexible sensors to generate electrocardiographs. Physicochemical or biological approaches are used to prepare Ag NPs; however, each method has its pros and cons. The prohibitive cost and use of hazardous chemicals hinder the application of physicochemical synthesis. Likewise, biological synthesis is not always reproducible for extensive use but can be a suitable candidate for therapeutic activities like cancer therapy. Excess use of Ag NPs is cytotoxic, and their unregulated discharge in the environment may have effects on both aquatic and terrestrial biota. The research in Ag NPs has always been driven by the need to develop a technology with potential benefits and minimal risk to environmental and human health. In this review, we have attempted to provide an insight into the application of Ag NPs in various sectors along with the recent synthetic and characterization techniques used for Ag NPs.