Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Casarotto, P.; Girych, M.; M. Fred, S.; Kovaleva, V.; Moliner, R.; Enkavi, Giray; Biojone, C.; Cannarozzo, C.; Sahu, Madhusmita; Kaurinkoski, Katja; Brunello, C.; Steinzeig, A.; Winkel, Frederike; Patil, Sudarshan; Vestring, S.; Serchov, T.; Diniz, C.; Laukkanen, L.; Cardon, Iseline; Antila, Hanna; Róg, T.; Petteri Piepponen, T.; Bramham, C.; Normann, Claus; Lauri, S.; Saarma, Mart; Vattulainen, I.; Castrén, E.

doi:10.1016/j.cell.2021.01.034

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Antidepressant drugs act by directly binding to TRKB neurotrophin receptors

Shared by NobleBlocks on Feb 12, 2021 • 12:00 AM UTC

Authors:

P. Casarotto

M. Girych

S. M. Fred

Abstract

Summary It is unclear how binding of antidepressant drugs to their targets gives rise to the clinical antidepressant effect. We discovered that the transmembrane domain of tyrosine kinase receptor 2 (TRKB), the brain-derived neurotrophic factor (BDNF) receptor that promotes neuronal plasticity and a...

Subject

Medicine

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