Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Ayton, Scott; G. Faux, Noel; Bush, A.; W. Paul Ronald Clifford R. William John Q. Arthur Weiner Aisen Petersen Jack Jr. Jagust Trojanowki T, Michael; W. Weiner, Michael; Aisen, P.; Petersen, Ronald; R. Jack Jr., Clifford; Jagust, W.; Trojanowki, J.; Toga, A.; Beckett, L.; Green, R.; Saykin, A.; Morris, J.; Shaw, L.; Khachaturian, Z.; Sorensen, Greg; Kuller, Lewis; Raichle, M.; Paul, S.; Davies, P.; Fillit, H.; Hefti, F.; Holtzman, D.; Marcel Mesulam, M.; Potter, W.; J. Snyder, Peter; Schwartz, Adam; Montine, T.; Thomas, R.; Donohue, M.; Walter, Sarah; Gessert, D.; Sather, T.; Jiminez, G.; Harvey, D.; Bernstein, M.; Fox, Nick; M. Thompson, Paul; Schuff, N.; J. Borowski, Bret; Gunter, J.; Senjem, M.; Vemuri, P.; Jones, David; Kantarci, K.; Ward, C.; Koeppe, R.; L. Foster, Normal; Reiman, E.; Chen, Kewei; Mathis, C.; M. Landau, Susan; Cairns, N.; Householder, E.; taylor-Reinwald, L.; Lee, V.; Korecka, M.; Figurski, M.; Crawford, K.; Neu, S.; Foroud, T.; Potkin, S.; Shen, Li; Faber, K.; Kim, Sungeun; Nho, K.; Thal, L.; Buckholtz, N.; Albert, M.; Frank, Richard; K. Hsiao, John; Kaye, J.; Quinn, J.; Lind, B.; Carter, R.; Dolen, S.; Schneider, L.; Pawluczyk, S.; Beccera, Mauricio; Teodoro, L.; M. Spann, Bryan; Brewer, J.; Vanderswag, H.; Fleisher, A.; Heidebrink, J.; Lord, J.; Mason, S.; Albers, C.; Knopman, D.; A. Johnson, Kris; Doody, R.; Villanueva-Meyer, J.; Chowdhury, M.; Rountree, S.; Dang, M.; Stern, Y.; Honig, L.; Bell, K.; Ances, B.; Carroll, M.; Leon, Sue; Mintun, M.; Schneider, S.; Oliver, A.; Marson, D.; Griffith, R.; Clark, D.; Geldmacher, D.; Brockington, J.; Roberson, E.; Grossman, H.; M. Mitsis, Effie; deToledo‐Morrell, L.; Shah, R.; Duara, R.; Varon, D.; T. Greig, Maria; Roberts, Peggy; S. Albert, Marilyn; Onyike, C.; D’Agostino II, Daniel; Kielb, S.; Galvin, J.; Cerbone, Brittany; A. Michel, Christina; Rusinek, H.; D. de Leon, M.; Glodzik, L.; de Santi, S.; Murali Doraiswamy, P.; Petrella, J.; Wong, T.; Arnold, S.; Karlawish, J.; Wolk, D.; D. Smith, Charles; Jicha, G.; Hardy, Peter; Sinha, P.; Oates, Elizabeth; Conrad, G.; Lopez, O.; Oakley, M.; Simpson, D.; Porsteinsson, A.; Goldstein, B.; Martin, K.; Makino, K.; Saleem Ismail, M.; Brand, C.; Mulnard, R.; Thai, G.; Mc-Adams-Ortiz, Catherine; Womack, K.; Mathews, D.; Quiceno, M.; Diaz‐Arrastia, Ramon; D. King, Richard; Weiner, Myron; Martin‐Cook, K.; Devous, M.; Levey, A.; Lah, J.; Cellar, J.; Burns, J.; Anderson, H.; Swerdlow, R.; Apostolova, L.; Tingus, K.; Woo, E.; Silverman, D.; Lu, P.; Bartzokis, G.; Graff-Radford, N.; Parfitt, F.; Kendall, Tracy; K. Johnson, Heather; Farlow, M.; Hake, A.; Matthews, B.; Herring, S.; Hunt, Cynthia; V. van Dyck, C.; Carson, R.; Macavoy, M.; Chertkow, H.; Bergman, H.; Hosein, C.; Black, S.; Stefanovic, B.; Caldwell, Curtis; Robin Hsiung, Ging‐Yuek; Feldman, H.; Mudge, B.; Assaly, M.; Kertesz, A.; Rogers, J.; Bernick, C.; Munic, D.; Kerwin, D.; Mesulam, M.; Lipowski, K.; Wu, Chuang‐Kuo; Johnson, N.; Sadowsky, C.; Martínez, Walter; Villena, Teresa; Scott Turner, R.; Johnson, K.; Reynolds, B.; Sperling, R.; Johnson, K.; Marshall, G.; T. Frey, Meghan; Lane, B.; Rosen, A.; Tinklenberg, J.; Sabbagh, M.; Belden, C.; Jacobson, S.; A. Sirrel, Sherye; Kowall, N.; Killiany, R.; Budson, A.; Norbash, A.; L. Johnson, P.; S. Allard, Joanne; Lerner, A.; Ogrocki, P.; Hudson, Leon; Fletcher, E.; Carmichael, Owen; Olichney, J.; Decarli, C.; Kittur, S.; Borrie, M.; Lee, T.; Bartha, R.; C. Johnson, Sterling; Asthana, S.; Carlsson, C.; Potkin, S.; Preda, Adrian; Nguyen, D.; Tariot, P.; A. Reeder, Stephanie; Bates, V.; Capote, H.; Rainka, M.; Scharre, D.; Kataki, M.; Adeli, Anahita; Zimmerman, E.; Celmins, D.; D. Brown, Alice; Pearlson, G.; Blank, K.; Anderson, K.; Santulli, R.; Kitzmiller, T.; Schwartz, E.; Sink, K.; Williamson, J.; Garg, P.; Watkins, F.; L. Ott, Brian; Querfurth, H.; Tremont, G.; Salloway, S.; Malloy, P.; Correia, S.; Rosen, H.; Miller, B.; Mintzer, J.; Spicer, K.; Bachman, D.; Finger, E.; Pasternak, S.; Rachinsky, I.; Drost, D.; Pomara, N.; Hernando, R.; Sarrael, A.; Schultz, S.; L. Boles Ponto, L.; Shim, H.; Elizabeth Smith, Karen; Relkin, N.; Chaing, G.; Raudin, Lisa; G. Smith, Amanda; Fargher, K.; Ashok Raj, Balebail; Neylan, T.; Grafman, J.; Davis, M.; H. Morrison, Rosemary; Hayes, J.; Finley, Shannon; Friedl, K.; Fleischman, D.; Arfanakis, K.; James, O.; Massoglia, D.; Jay Fruehling, J.; Harding, Sandra; Peskind, E.; Petrie, E.; Li, Gail; Yesavage, J.; Taylor, Joy; Furst, A.

doi:10.1038/ncomms7760

Public

Ferritin levels in the cerebrospinal fluid predict Alzheimer's disease outcomes and are regulated by APOE

Shared by NobleBlocks on May 19, 2015 • 12:00 AM UTC

Authors:

Scott Ayton

Noel G. Faux

A. Bush

Abstract

Brain iron elevation is implicated in Alzheimer’s disease (AD) pathogenesis, but the impact of iron on disease outcomes has not been previously explored in a longitudinal study. Ferritin is the major iron storage protein of the body; by using cerebrospinal fluid (CSF) levels of ferritin as an index,...

Subject

Medicine

Biology

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