Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

Huffman, J.; Albrecht, E.; Teumer, A.; Mangino, M.; Kapur, K.; Johnson, T.; Kutalik, Z.; Pirastu, N.; Pistis, G.; M. Lopez, Lorna; Haller, T.; Salo, P.; Goel, A.; Li, Man; Tanaka, Toshiko; Dehghan, A.; Ruggiero, D.; Malerba, G.; Smith, A.; Nolte, I.; Portas, L.; Phipps-Green, A.; Boteva, L.; Navarro, P.; Johansson, Å.; Hicks, A.; Polašek, O.; Esko, T.; Peden, J.; Harris, S.; Murgia, Federico; Wild, S.; Tenesa, A.; Tin, A.; Mihailov, E.; Grotevendt, Anne; Gíslason, G.; Coresh, J.; D'Adamo, P.; Ulivi, Sheila; Vollenweider, P.; Waeber, G.; Campbell, Susan; Kolčić, I.; Fisher, Krista; Viigimaa, M.; E. Metter, Jeffrey; Masciullo, C.; Trabetti, E.; Bombieri, C.; Sorice, R.; Döring, A.; Reischl, E.; Strauch, K.; Hofman, A.; Uitterlinden, A.; Waldenberger, M.; Wichmann, H.; Davies, G.; Gow, A.; Dalbeth, N.; Stamp, L.; Smit, J.; Kirin, M.; Nagaraja, R.; Nauck, M.; Schurmann, C.; Budde, Kathrin; Farrington, S.; Theodoratou, E.; Jula, A.; Salomaa, V.; Sala, C.; Hengstenberg, C.; Burnier, M.; Mägi, R.; Klopp, N.; Kloiber, S.; Schipf, S.; Ripatti, S.; Cabras, S.; Soranzo, N.; Homuth, G.; Nutile, T.; Munroe, P.; Hastie, N.; Campbell, H.; Rudan, I.; Cabrera, C.; Haley, C.; Franco, O.; Merriman, T.; Gudnason, V.; Pirastu, M.; Penninx, B.; Snieder, H.; Metspalu, A.; Ciullo, M.; Pramstaller, P.; M. van Duijn, Cornelia; Ferrucci, L.; Gambaro, G.; Deary, I.; Dunlop, M.; F. Wilson, James; Gasparini, P.; Gyllensten, U.; Spector, T.; Wright, A.; Hayward, C.; Watkins, H.; Perola, M.; Bochud, M.; Kao, W.; Caulfield, M.; Toniolo, D.; Völzke, H.; Gieger, C.; Köttgen, A.; Vitart, V.

doi:10.1371/journal.pone.0119752

Public

Modulation of Genetic Associations with Serum Urate Levels by Body-Mass-Index in Humans

Shared by NobleBlocks on Mar 26, 2015 • 12:00 AM UTC

Authors:

J. Huffman

E. Albrecht

A. Teumer

Abstract

We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-s...

Subject

Medicine

Biology

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!