Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target.

K, Tsumoto; S, Misawa; Y, Ohba; T, Ueno; H, Hayashi; N, Kasai; H, Watanabe; R, Asano; I, Kumagai

doi:10.1016/s0014-5793(02)03090-9

Public

Inhibition of hepatitis C virus NS3 protease by peptides derived from complementarity-determining regions (CDRs) of the monoclonal antibody 8D4: tolerance of a CDR peptide to conformational changes of a target.

Shared by NobleBlocks on Aug 1, 2002 • 12:00 AM UTC

Authors:

Tsumoto K

Misawa S

Ohba Y

Abstract

We have synthesized and characterized peptides derived from complementarity-determining regions (CDRs) of 8D4, a mouse monoclonal antibody against NS3 protease domain of hepatitis C virus. 8D4 inhibits enzymatic activity without its cofactor, NS4A peptide. One of the synthetic peptides derived from ...

Research Assistant

AI chat, annotations, notes & similar papers

Finding related papers...

Discussions

(0)

No comments yet

Be the first to share your thoughts!