Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells.

Q, Li; J, Ren; D, Kufe

doi:10.1016/j.bbrc.2004.01.075

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Interaction of human MUC1 and beta-catenin is regulated by Lck and ZAP-70 in activated Jurkat T cells.

Published in Biochemical and biophysical research communications • Mar 1, 2004

Authors:

Li Q

Ren J

Kufe D

Abstract

The MUC1 transmembrane glycoprotein is aberrantly expressed by diverse hematologic malignancies, including those of the T cell lineage. The MUC1 cytoplasmic domain (CD) interacts with beta-catenin; however, the role of MUC1 in T cells is not known. In the present work, MUC1 was studied as a potentia...

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