Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus.

K, Kawaguchi; RW, Hickey; ME, Rose; L, Zhu; J, Chen; SH, Graham

doi:10.1016/j.brainres.2005.05.038

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Cyclooxygenase-2 expression is induced in rat brain after kainate-induced seizures and promotes neuronal death in CA3 hippocampus.

Shared by NobleBlocks on Jul 1, 2005 • 12:00 AM UTC

Authors:

Kawaguchi K

Hickey RW

Rose ME

Abstract

Cyclooxygenase-2 (COX-2) is the predominant isoform of cyclooxygenase in brain. COX-2 activity produces oxidative stress and results in the production of prostaglandins that have many injurious effects. COX-2 transcription is induced by synaptic activity; therefore, COX-2 activity could contribute t...

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