Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.

Böhm, M; Brückner, R; Neumann, J; Nose, M; Schmitz, W; Scholz, H

doi:10.1111/j.1476-5381.1988.tb11456.x

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Adenosine inhibits the positive inotropic effect of 3-isobutyl-1-methylxanthine in papillary muscles without effect on cyclic AMP or cyclic GMP.

Shared by NobleBlocks on Apr 1, 1988 • 12:00 AM UTC

Authors:

M Böhm

R Brückner

J Neumann

Abstract

1 Adenosine and the adenosine receptor agonist (-)-N6-phenylisopropyladenosine (PIA) produced a small positive and negative inotropic effect, respectively, in isolated electrically driven papillary muscles of guinea-pigs. 2 Adenosine (100 mumol l-1) had no effect on cyclic AMP or cyclic GMP content....

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