Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults.

Sanami, Safa; Rezaei, Ali; A Tremblay, Stéfanie; Potvin-Jutras, Zacharie; Sabra, Dalia; Intzandt, Brittany; Gagnon, Christine; Mainville-Berthiaume, Amélie; Wright, Lindsay; Gayda, Mathieu; Iglesies-Grau, Josep; Nigam, Anil; Bherer, Louis; J Gauthier, Claudine

doi:10.1177/0271678x251413924

Public

Greater cardiorespiratory fitness is associated with higher cerebral blood flow and lower oxygen extraction fraction in healthy older adults.

Shared by NobleBlocks on Jan 16, 2026 • 12:00 AM UTC

Authors:

Safa Sanami

Ali Rezaei

Stéfanie A Tremblay

Abstract

Aerobic exercise training promotes cardiovascular, brain and cognitive health. Regular exercise is associated with higher cardiorespiratory fitness, commonly assessed by peak oxygen uptake (VO2peak) during maximal effort testing. Higher cardiorespiratory fitness has been linked to preserved brain he...

Subject

Cerebral blood flow

cerebral metabolic rate of oxygen consumption

dual calibrated functional MRI

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