Chemically pure nicotine in dose 0.4, 1.5 and 5.0 mg/kg bw were percutaneously injected into Wistar rats during 1-20 (I) and 1-8 days (II) of pregnancy. The gametotoxic effect of nicotine in two-month males from offspring of the first generation (F1) was observed in disturbance of differentiation dy...
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