Positron emission tomographic studies of [11C]MDL 72222, a potential 5-HT3 receptor radioligand: distribution, kinetics and binding in the brain of the baboon.

R, Camsonne; L, Barre; MC, Petit-Taboué; JM, Travère; R, Jones; D, Debruyne; MA, Moulin; ET, MacKenzie; JC, Baron

doi:10.1016/0028-3908(93)90131-l

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Positron emission tomographic studies of [11C]MDL 72222, a potential 5-HT3 receptor radioligand: distribution, kinetics and binding in the brain of the baboon.

Shared by NobleBlocks on Jan 1, 1993 • 12:00 AM UTC

Authors:

Camsonne R

Barre L

Petit-Taboué MC

Abstract

The drug MDL 72222, a selective 5-HT3 receptor antagonist, was labelled with 11C and evaluated for distribution kinetics in brain and in vivo binding to 5-HT3 receptors using cold MDL 72222 challenge and positron emission tomography (PET), in three anaesthetized baboons. After tracer doses of [11C]M...

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