A new non-linear normalization method for reducing variability in DNA microarray experiments

T. Workman, Christopher; Juhl Jensen, Lars; Jarmer, Hanne; M. Berka, Randy; Gautier, Laurent; Bjørn Nielsen, Henrik; Saxild, Hans-Henrik; Henrik Nielsen, Claus; Brunak, Søren; Knudsen, Steen

doi:10.1186/gb-2002-3-9-research0048

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A new non-linear normalization method for reducing variability in DNA microarray experiments

Published in Genome biology • Aug 30, 2002

Authors:

Christopher T. Workman

Lars Juhl Jensen

Hanne Jarmer

Abstract

BACKGROUND: Microarray data are subject to multiple sources of variation, of which biological sources are of interest whereas most others are only confounding. Recent work has identified systematic sources of variation that are intensity-dependent and non-linear in nature. Systematic sources of vari...

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Subject

Normalization (sociology)

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Computer science

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