No .NO from NO synthase.

HH, Schmidt; H, Hofmann; U, Schindler; ZS, Shutenko; DD, Cunningham; M, Feelisch

doi:10.1073/pnas.93.25.14492

Public

No .NO from NO synthase.

Shared by NobleBlocks on Dec 1, 1996 • 12:00 AM UTC

Authors:

Schmidt HH

Hofmann H

Schindler U

Abstract

The nitric-oxide synthase (NOS; EC 1.14.13.39) reaction is formulated as a partially tetrahydrobiopterin (H4Bip)-dependent 5-electron oxidation of a terminal guanidino nitrogen of L-arginine (Arg) associated with stoichiometric consumption of dioxygen (O2) and 1.5 mol of NADPH to form L-citrulline (...

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