Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria.

DH, Hyun; ND, Hunt; SS, Emerson; JO, Hernandez; MP, Mattson; Cabo R, de; Cabo R, de

doi:10.1111/j.1471-4159.2006.04411.x

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Up-regulation of plasma membrane-associated redox activities in neuronal cells lacking functional mitochondria.

Shared by NobleBlocks on Jan 22, 2007 • 12:00 AM UTC

Authors:

Hyun DH

Hunt ND

Emerson SS

Abstract

Mitochondria-deficient cells (rho(o) cells) survive through enhanced glycolytic metabolism in the presence of pyruvate and uridine. The plasma membrane redox system (PMRS) contains several NAD(P)H-related enzymes and plays a key role in maintaining the levels of NAD(+)/NADH and reduced coenzyme Q. I...

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