IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.

E, Schmitt; T, Germann; S, Goedert; P, Hoehn; C, Huels; S, Koelsch; R, Kühn; W, Müller; N, Palm; E, Rüde

doi:10.4049/jimmunol.153.9.3989

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IL-9 production of naive CD4+ T cells depends on IL-2, is synergistically enhanced by a combination of TGF-beta and IL-4, and is inhibited by IFN-gamma.

Shared by NobleBlocks on Nov 1, 1994 • 12:00 AM UTC

Authors:

Schmitt E

Germann T

Goedert S

Abstract

Dense CD4+ T cells isolated from naive mice produce only trace amounts of IL-9 when stimulated by immobilized anti-CD3 in combination with anti-CD28 Abs. In this situation, IL-9 production is significantly stimulated by TGF-beta and further enhanced by the addition of IL-4, which, by itself, has onl...

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