Structural features in eukaryotic mRNAs that modulate the initiation of translation.

In higher eukaryotes, translation is modulated at the level of initiation by five aspects of mRNA structure: (i) the m7G cap; (ii) the primary sequence or context surrounding the AUG codon; (iii) the position of the AUG codon, i.e. whether or not it s “first”; (iv) secondary structure both upstream ... View More