Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase.

der Wijst MG, van; M, Venkiteswaran; H, Chen; GL, Xu; T, Plösch; MG, Rots

doi:10.1080/15592294.2015.1062204

Public

Local chromatin microenvironment determines DNMT activity: from DNA methyltransferase to DNA demethylase or DNA dehydroxymethylase.

Shared by NobleBlocks on Jan 1, 2015 • 12:00 AM UTC

Authors:

van der Wijst MG

Venkiteswaran M

Chen H

Abstract

Insights on active DNA demethylation disproved the original assumption that DNA methylation is a stable epigenetic modification. Interestingly, mammalian DNA methyltransferases 3A and 3B (DNMT-3A and -3B) have also been reported to induce active DNA demethylation, in addition to their well-known fun...

Subject

DNA demethylation

Dnmts

Dnmt

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