Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.

MV, Holmes; T, Simon; HJ, Exeter; L, Folkersen; FW, Asselbergs; M, Guardiola; JA, Cooper; J, Palmen; JA, Hubacek; KF, Carruthers; BD, Horne; KD, Brunisholz; JL, Mega; Iperen EPA, van; M, Li; M, Leusink; S, Trompet; JJW, Verschuren; GK, Hovingh; A, Dehghan; CP, Nelson; S, Kotti; N, Danchin; M, Scholz; CL, Haase; D, Rothenbacher; DI, Swerdlow; KB, Kuchenbaecker; E, Staines-Urias; A, Goel; 't Hooft F, van; K, Gertow; Faire U, de; AG, Panayiotou; E, Tremoli; D, Baldassarre; F, Veglia; LM, Holdt; F, Beutner; RT, Gansevoort; GJ, Navis; Leach I, Mateo; LP, Breitling; H, Brenner; J, Thiery; D, Dallmeier; A, Franco-Cereceda; JMA, Boer; JW, Stephens; MH, Hofker; A, Tedgui; A, Hofman; AG, Uitterlinden; V, Adamkova; J, Pitha; NC, Onland-Moret; MJ, Cramer; HM, Nathoe; W, Spiering; OH, Klungel; M, Kumari; PH, Whincup; DA, Morrow; PS, Braund; AS, Hall; AG, Olsson; PA, Doevendans; MD, Trip; MD, Tobin; A, Hamsten; H, Watkins; W, Koenig; AN, Nicolaides; D, Teupser; INM, Day; JF, Carlquist; TR, Gaunt; I, Ford; N, Sattar; S, Tsimikas; GG, Schwartz; DA, Lawlor; RW, Morris; MS, Sandhu; R, Poledne; der Zee AH, Maitland-van; KT, Khaw; BJ, Keating; der Harst P, van; JF, Price; SR, Mehta; S, Yusuf; JCM, Witteman; OH, Franco; JW, Jukema; Knijff P, de; A, Tybjaerg-Hansen; DJ, Rader; M, Farrall; NJ, Samani; M, Kivimaki; KAA, Fox; SE, Humphries; JL, Anderson; SM, Boekholdt; TM, Palmer; P, Eriksson; G, Paré; AD, Hingorani; MS, Sabatine; Z, Mallat; JP, Casas; PJ, Talmud

doi:10.1016/j.jacc.2013.06.044

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Secretory phospholipase A(2)-IIA and cardiovascular disease: a mendelian randomization study.

Published in Journal of the American College of Cardiology • Jul 31, 2013

Authors:

Holmes MV

Simon T

Exeter HJ

Abstract

<h4>Objectives</h4>This study sought to investigate the role of secretory phospholipase A2 (sPLA2)-IIA in cardiovascular disease.<h4>Background</h4>Higher circulating levels of sPLA2-IIA mass or sPLA2 enzyme activity have been associated with increased risk of cardiovascular events. However, it is n...

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Open Access

Subject

Genetics

Cardiovascular diseases

Myocardial infarction

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