Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.

Fujiwara, Toshiyuki; Oda, Kazutaka; Yokota, Sadaki; Takatsuki, Akira; Ikehara, Yuzuru

doi:10.1016/s0021-9258(19)81393-5

Public

Brefeldin A causes disassembly of the Golgi complex and accumulation of secretory proteins in the endoplasmic reticulum.

Shared by NobleBlocks on Dec 1, 1988 • 12:00 AM UTC

Authors:

Toshiyuki Fujiwara

Kazutaka Oda

Sadaki Yokota

Abstract

The antiviral antibiotic brefeldin A (BFA) strongly inhibits the protein secretion in cultured rat hepatocytes (Misumi, Y., Misumi, Y., Miki, K., Takatsuki, A., Tamura, G., and Ikehara, Y. (1986) J. Biol. Chem. 261, 11398-11403). We have further examined the inhibitory effect of the drug on intracel...

Subject

Endoplasmic reticulum

Brefeldin A

Golgi apparatus

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