Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse.

JA, Araujo; L, Meng; AD, Tward; WW, Hancock; Y, Zhai; A, Lee; K, Ishikawa; S, Iyer; R, Buelow; RW, Busuttil; DM, Shih; AJ, Lusis; JW, Kupiec-Weglinski

doi:10.4049/jimmunol.171.3.1572

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Systemic rather than local heme oxygenase-1 overexpression improves cardiac allograft outcomes in a new transgenic mouse.

Shared by NobleBlocks on Aug 1, 2003 • 12:00 AM UTC

Authors:

Araujo JA

Meng L

Tward AD

Abstract

Heme oxygenase-1 (HO-1), a rate-limiting enzyme in heme catabolism, exhibits potent antioxidant and anti-inflammatory properties. We developed HO-1 transgenic (Tg) mice using a rat HO-1 genomic transgene under the control of the endogenous promoter. Transgene expression was demonstrated by RT-PCR in...

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