Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects.

CS, Palmer; JJ, Anzinger; J, Zhou; M, Gouillou; A, Landay; A, Jaworowski; JM, McCune; SM, Crowe

doi:10.4049/jimmunol.1303092

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Glucose transporter 1-expressing proinflammatory monocytes are elevated in combination antiretroviral therapy-treated and untreated HIV+ subjects.

Shared by NobleBlocks on Nov 3, 2014 • 12:00 AM UTC

Authors:

Palmer CS

Anzinger JJ

Zhou J

Abstract

Monocyte activation during HIV-1 infection is associated with increased plasma levels of inflammatory markers and increased risk for premature development of age-related diseases. Because activated monocytes primarily use glucose to support cellular metabolism, we hypothesized that chronic monocyte ...

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