Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group.

Y, Muto; H, Moriwaki; M, Ninomiya; S, Adachi; A, Saito; KT, Takasaki; T, Tanaka; K, Tsurumi; M, Okuno; E, Tomita; T, Nakamura; T, Kojima

doi:10.1056/nejm199606133342402

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Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group.

Shared by NobleBlocks on Jun 1, 1996 • 12:00 AM UTC

Authors:

Muto Y

Moriwaki H

Ninomiya M

Abstract

<h4>Background</h4>In patients with hepatocellular carcinoma (hepatoma), the rate of recurrent and second primary hepatomas is high despite surgical resection and percutaneous ethanol-injection therapy. We developed an acyclic retinoid, polyprenoic acid, that inhibits hepatocarcinogenesis in the lab...

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