Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen.

T, Hanke; RV, Samuel; TJ, Blanchard; VC, Neumann; TM, Allen; JE, Boyson; SA, Sharpe; N, Cook; GL, Smith; DI, Watkins; MP, Cranage; AJ, McMichael

doi:10.1128/jvi.73.9.7524-7532.1999

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Effective induction of simian immunodeficiency virus-specific cytotoxic T lymphocytes in macaques by using a multiepitope gene and DNA prime-modified vaccinia virus Ankara boost vaccination regimen.

Shared by NobleBlocks on Sep 1, 1999 • 12:00 AM UTC

Authors:

Hanke T

Samuel RV

Blanchard TJ

Abstract

DNA and modified vaccinia virus Ankara (MVA) are vaccine vehicles suitable and safe for use in humans. Here, by using a multicytotoxic T-lymphocyte (CTL) epitope gene and a DNA prime-MVA boost vaccination regimen, high levels of CTLs specific for a single simian immunodeficiency virus (SIV) gag-deri...

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