Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG.

U, Båve; M, Magnusson; ML, Eloranta; A, Perers; GV, Alm; L, Rönnblom

doi:10.4049/jimmunol.171.6.3296

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Fc gamma RIIa is expressed on natural IFN-alpha-producing cells (plasmacytoid dendritic cells) and is required for the IFN-alpha production induced by apoptotic cells combined with lupus IgG.

Shared by NobleBlocks on Sep 1, 2003 • 12:00 AM UTC

Authors:

Båve U

Magnusson M

Eloranta ML

Abstract

An ongoing production of IFN-alpha may be of etiopathogenic significance in systemic lupus erythematosus (SLE). It may be due to the natural IFN-producing cells (NIPC), also termed plasmacytoid dendritic cells (PDC), activated by immune complexes that contain nucleic acids derived from apoptotic cel...

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