Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B.

D, Xu; J, Fu; L, Jin; H, Zhang; C, Zhou; Z, Zou; JM, Zhao; B, Zhang; M, Shi; X, Ding; Z, Tang; YX, Fu; FS, Wang

doi:10.4049/jimmunol.177.1.739

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Circulating and liver resident CD4+CD25+ regulatory T cells actively influence the antiviral immune response and disease progression in patients with hepatitis B.

Published in Journal of immunology (Baltimore, Md. : 1950) • Jul 1, 2006

Authors:

Xu D

Fu J

Jin L

Abstract

CD4+CD25+ regulatory T cells (Treg) have been shown to maintain immune tolerance against self and foreign Ags, but their role in persistent viral infection has not been well-defined. In this study, we investigated whether and where CD4+CD25+ Treg contribute to the development of chronic hepatitis B ...

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