Involvement of IL-6 in mesangial proliferative glomerulonephritis.

Horii, Yuko; Muraguchi, Atsushi; Iwano, Masayuki; Matsuda, T.; Hirayama, T; Yamada, Hirotsugu; Fujii, Yuichi; Dohi, Kazuhiro; Ishikawa, Hideaki; Ohmoto, Yasukazu; Yoshizaki, K; Hirano, T; Kishimoto, T

doi:10.4049/jimmunol.143.12.3949

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Involvement of IL-6 in mesangial proliferative glomerulonephritis.

Shared by NobleBlocks on Dec 1, 1989 • 12:00 AM UTC

Authors:

Yuko Horii

Atsushi Muraguchi

Masayuki Iwano

Abstract

In this study, we demonstrated that IL-6 was a possible autocrine growth factor for rat mesangial cells (MC). rIL-6 induced in vitro growth of rat MC at a concentration of 2 to 200 ng/ml and IL-6 activity was found in the supernatant of cultured rat MC. Northern blot analysis as well as in situ hybr...

Subject

Mesangial proliferative glomerulonephritis

Urine

Glomerulonephritis

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