Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

JM, Carthy; A, Sundqvist; A, Heldin; Dam H, van; D, Kletsas; CH, Heldin; A, Moustakas

doi:10.1002/jcp.25049

Public

Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.

Shared by NobleBlocks on Dec 1, 2015 • 12:00 AM UTC

Authors:

Carthy JM

Sundqvist A

Heldin A

Abstract

Transforming growth factor-β (TGF-β) is a multifunctional cytokine which stimulates the differentiation of fibroblasts into myofibroblasts. Myofibroblasts are critical for normal wound healing, but also accumulate pathologically in a number of chronic inflammatory conditions where they are key contr...

Discussions