Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX.

J, Leitans; A, Kazaks; A, Balode; J, Ivanova; R, Zalubovskis; CT, Supuran; K, Tars

doi:10.1021/acs.jmedchem.5b01343

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Efficient Expression and Crystallization System of Cancer-Associated Carbonic Anhydrase Isoform IX.

Shared by NobleBlocks on Nov 10, 2015 • 12:00 AM UTC

Authors:

Leitans J

Kazaks A

Balode A

Abstract

Human carbonic anhydrase IX (CA IX) is overexpressed in a number of solid tumors and is considered to be a marker for cellular hypoxia that it is not produced in most normal tissues. CA IX contributes to the acidification of the extracellular matrix, which, in turn, favors tumor growth and metastasi...

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