The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.

PW, Harms; P, Vats; ME, Verhaegen; DR, Robinson; YM, Wu; SM, Dhanasekaran; N, Palanisamy; J, Siddiqui; X, Cao; F, Su; R, Wang; H, Xiao; LP, Kunju; R, Mehra; SA, Tomlins; DR, Fullen; CK, Bichakjian; TM, Johnson; AA, Dlugosz; AM, Chinnaiyan

doi:10.1158/0008-5472.can-15-0702

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The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma.

Shared by NobleBlocks on Aug 3, 2015 • 12:00 AM UTC

Authors:

Harms PW

Vats P

Verhaegen ME

Abstract

Merkel cell carcinoma (MCC) is a rare but highly aggressive cutaneous neuroendocrine tumor. Merkel cell polyomavirus (MCPyV) may contribute to tumorigenesis in a subset of tumors via inhibition of tumor suppressors such as retinoblastoma (RB1) by mutated viral T antigens, but the molecular pathogene...

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