Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

Moor MH, de; den Berg SM, van; KJ, Verweij; RF, Krueger; M, Luciano; Vasquez A, Arias; LK, Matteson; J, Derringer; T, Esko; N, Amin; SD, Gordon; NK, Hansell; AB, Hart; I, Seppälä; JE, Huffman; B, Konte; J, Lahti; M, Lee; M, Miller; T, Nutile; T, Tanaka; A, Teumer; A, Viktorin; J, Wedenoja; GR, Abecasis; DE, Adkins; A, Agrawal; J, Allik; K, Appel; TB, Bigdeli; F, Busonero; H, Campbell; PT, Costa; Smith G, Davey; G, Davies; Wit H, de; J, Ding; BE, Engelhardt; JG, Eriksson; IO, Fedko; L, Ferrucci; B, Franke; I, Giegling; R, Grucza; AM, Hartmann; AC, Heath; K, Heinonen; AK, Henders; G, Homuth; JJ, Hottenga; WG, Iacono; J, Janzing; M, Jokela; R, Karlsson; JP, Kemp; MG, Kirkpatrick; A, Latvala; T, Lehtimäki; DC, Liewald; PA, Madden; C, Magri; PK, Magnusson; J, Marten; A, Maschio; SE, Medland; E, Mihailov; Y, Milaneschi; GW, Montgomery; M, Nauck; KG, Ouwens; A, Palotie; E, Pettersson; O, Polasek; Y, Qian; L, Pulkki-Råback; OT, Raitakari; A, Realo; RJ, Rose; D, Ruggiero; CO, Schmidt; WS, Slutske; R, Sorice; JM, Starr; Pourcain B, St; AR, Sutin; NJ, Timpson; H, Trochet; S, Vermeulen; E, Vuoksimaa; E, Widen; J, Wouda; MJ, Wright; L, Zgaga; D, Porteous; A, Minelli; AA, Palmer; D, Rujescu; M, Ciullo; C, Hayward; I, Rudan; A, Metspalu; J, Kaprio; IJ, Deary; K, Räikkönen; JF, Wilson; L, Keltikangas-Järvinen; LJ, Bierut; JM, Hettema; HJ, Grabe; Duijn CM, van; DM, Evans; D, Schlessinger; NL, Pedersen; A, Terracciano; M, McGue; BW, Penninx; NG, Martin; DI, Boomsma

doi:10.1001/jamapsychiatry.2015.0554

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Meta-analysis of Genome-wide Association Studies for Neuroticism, and the Polygenic Association With Major Depressive Disorder.

Shared by NobleBlocks on Jul 1, 2015 • 12:00 AM UTC

Authors:

de Moor MH

van den Berg SM

Verweij KJ

Abstract

<h4>Importance</h4>Neuroticism is a pervasive risk factor for psychiatric conditions. It genetically overlaps with major depressive disorder (MDD) and is therefore an important phenotype for psychiatric genetics. The Genetics of Personality Consortium has created a resource for genome-wide associati...

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