EGFR tyrosine kinase domain mutations are detected in histologically normal respiratory epithelium in lung cancer patients.

To determine whether EGFR tyrosine kinase domain mutations are early events in the pathogenesis of lung adenocarcinomas, we tested for the presence of EGFR mutations in histologically normal bronchial and bronchiolar epithelia from lung adenocarcinomas bearing the common EGFR mutations. DNA was extr... View More