Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.

H, Asao; C, Okuyama; S, Kumaki; N, Ishii; S, Tsuchiya; D, Foster; K, Sugamura

doi:10.4049/jimmunol.167.1.1

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Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex.

Shared by NobleBlocks on Jul 1, 2001 • 12:00 AM UTC

Authors:

Asao H

Okuyama C

Kumaki S

Abstract

The common gamma-chain (gamma(c)) is an indispensable subunit of the functional receptor complexes for IL-4, IL-7, IL-9, and IL-15 as well as IL-2. Here we show that the gamma(c) is also shared with the IL-21R complex. Although IL-21 binds to the IL-21R expressed on gamma(c)-deficient ED40515(-) cel...

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