Polyploidization and Functional Maturation Are Two Distinct Processes During Megakaryocytic Differentiation: Involvement of Cyclin-Dependent Kinase Inhibitor p21 in Polyploidization

Kikuchi, Jiro; Furukawa, Yusuke; Iwase, Satsuki; Terui, Yasuhito; Nakamura, Mitsuru; Kitagawa, Seiichi; Kitagawa, Masatoshi; Komatsu, Norio; Miura, Yasusada

doi:10.1182/blood.v89.11.3980

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Polyploidization and Functional Maturation Are Two Distinct Processes During Megakaryocytic Differentiation: Involvement of Cyclin-Dependent Kinase Inhibitor p21 in Polyploidization

Shared by NobleBlocks on Jun 1, 1997 • 12:00 AM UTC

Authors:

Jiro Kikuchi

Yusuke Furukawa

Satsuki Iwase

Abstract

The mechanism of megakaryocytic differentiation was investigated using human megakaryocytic leukemia cell line UT-7. Polyploidization of UT-7 cells was induced by the microtubule-depolymerizing agent, nocodazole, and 12-O-tetradecanoylphorbol-13-acetate (TPA), but the effect was much more striking w...

Subject

Nocodazole

Biology

Cell biology

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