Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

Zhao, Shimin; Lin, Yan; Xu, Wei; Jiang, Wenqing; Zha, Zhengyu; Wang, Pu; Yu, Wei; Li, Zhiqiang; Gong, Lingling; Peng, Yingjie; Ding, Jianping; Lei, Qunying; Guan, Kun-Liang; Xiong, Yue

doi:10.1126/science.1170944

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Glioma-derived mutations in IDH1 dominantly inhibit IDH1 catalytic activity and induce HIF-1alpha.

Shared by NobleBlocks on Apr 10, 2009 • 12:00 AM UTC

Authors:

Shimin Zhao

Yan Lin

Wei Xu

Abstract

Heterozygous mutations in the gene encoding isocitrate dehydrogenase-1 (IDH1) occur in certain human brain tumors, but their mechanistic role in tumor development is unknown. We have shown that tumor-derived IDH1 mutations impair the enzyme's affinity for its substrate and dominantly inhibit wild-ty...

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