Thioflavin T as an efficient inducer and selective fluorescent sensor for the human telomeric G-quadruplex DNA.

Mohanty, Jyotirmayee; Barooah, Nilotpal; Dhamodharan, V; Harikrishna, S; I Pradeepkumar, P; C Bhasikuttan, Achikanath

doi:10.1021/ja309588h

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Thioflavin T as an efficient inducer and selective fluorescent sensor for the human telomeric G-quadruplex DNA.

Shared by NobleBlocks on Jan 9, 2013 • 12:00 AM UTC

Authors:

Jyotirmayee Mohanty

Nilotpal Barooah

V Dhamodharan

Abstract

The quest for a G-quadruplex specific fluorescent sensor among other DNA forms under physiological salt conditions has been addressed in this article. We demonstrate for the first time the application of a water-soluble fluorogenic dye, Thioflavin T (ThT), in a dual role of exclusively inducing quad...

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